Recipient-donor matching characteristics
| . | MUD, n (%) . | MMUD, n (%) . | Level of mismatch . |
|---|---|---|---|
| Blood group | |||
| Matched | 51 (48) | 18 (36) | |
| Major incompatibility | 21 (20) | 16 (32) | |
| Minor incompatibility | 28 (26) | 15 (30) | |
| Bidirectional | 7 (7) | 1 (2) | |
| Sex | |||
| Matched | 57 (53) | 28 (56) | |
| Male recipient, female donor | 20 (19) | 11 (22) | |
| Female recipient, male donor | 29 (27) | 11 (22) | |
| Missing data | 1 (1) | ||
| HLA match | |||
| Single class I mismatch | N/A | 18 (36) | |
| -A | N/A | 5 (10) | 5 antigenic |
| -B | N/A | 0 (0) | |
| -C | N/A | 13 (26) | 12 antigenic, 1 allelic |
| Single class II mismatch | N/A | 14 (28) | |
| DQB1 | N/A | 9 (18) | 6 antigenic, 3 allelic |
| DRB1 | N/A | 5 (10) | 5 allelic |
| 2 loci mismatch | N/A | 15 (30) | |
| Both class I | N/A | 7 (14) | 4 antigenic, 3 mixed |
| Both class II | N/A | 0 (0) | |
| Class I and II | N/A | 8 (16) | 3 antigenic, 1 allelic, 4 mixed |
| 3+ loci mismatch | N/A | 3 (6) | 3 mixed* |
| CMV status (recipient/donor)† | |||
| −/− | 61 (57) | 16 (32) | |
| −/+ | 11 (10) | 3 (6) | |
| +/− | 11 (10) | 13 (26) | |
| +/+ | 24 (22) | 18 (36) | |
| Stem cell source | |||
| BM | 42 (39) | 16 (32) | |
| PBSC | 65 (61) | 34 (68) | |
| Stem cell dose | |||
| CD34 ×106/kg (range) | 5.2 (0.6-18.5) | 5.7 (0.7-29) | |
| CFU × 104/kg (range) | 181 (24-465) | 171 (51-331) |
| . | MUD, n (%) . | MMUD, n (%) . | Level of mismatch . |
|---|---|---|---|
| Blood group | |||
| Matched | 51 (48) | 18 (36) | |
| Major incompatibility | 21 (20) | 16 (32) | |
| Minor incompatibility | 28 (26) | 15 (30) | |
| Bidirectional | 7 (7) | 1 (2) | |
| Sex | |||
| Matched | 57 (53) | 28 (56) | |
| Male recipient, female donor | 20 (19) | 11 (22) | |
| Female recipient, male donor | 29 (27) | 11 (22) | |
| Missing data | 1 (1) | ||
| HLA match | |||
| Single class I mismatch | N/A | 18 (36) | |
| -A | N/A | 5 (10) | 5 antigenic |
| -B | N/A | 0 (0) | |
| -C | N/A | 13 (26) | 12 antigenic, 1 allelic |
| Single class II mismatch | N/A | 14 (28) | |
| DQB1 | N/A | 9 (18) | 6 antigenic, 3 allelic |
| DRB1 | N/A | 5 (10) | 5 allelic |
| 2 loci mismatch | N/A | 15 (30) | |
| Both class I | N/A | 7 (14) | 4 antigenic, 3 mixed |
| Both class II | N/A | 0 (0) | |
| Class I and II | N/A | 8 (16) | 3 antigenic, 1 allelic, 4 mixed |
| 3+ loci mismatch | N/A | 3 (6) | 3 mixed* |
| CMV status (recipient/donor)† | |||
| −/− | 61 (57) | 16 (32) | |
| −/+ | 11 (10) | 3 (6) | |
| +/− | 11 (10) | 13 (26) | |
| +/+ | 24 (22) | 18 (36) | |
| Stem cell source | |||
| BM | 42 (39) | 16 (32) | |
| PBSC | 65 (61) | 34 (68) | |
| Stem cell dose | |||
| CD34 ×106/kg (range) | 5.2 (0.6-18.5) | 5.7 (0.7-29) | |
| CFU × 104/kg (range) | 181 (24-465) | 171 (51-331) |
Recipient-donor matching for blood group, sex, HLA, and CMV stratified according to 10/10 HLA match (MUD) or 6 to 9/10 HLA match (MMUD). BM indicates bone marrow; CFU, colony-forming unit; N/A, not applicable; and PBSC, peripheral blood stem cell.
Two mismatched at 2 antigens + 1 allele, and one at 3 antigens + 1 allele.
P < .01. P values (χ2 test) for all other factors were not significant.