Expression of the genes uniquely deregulated in Cbfb+/MYH11 embryos in mouse and human leukemias
| Gene symbol . | Gene name . | Fold change in Cbfb-MYH embryos . | Expressed in Cbfb-MYH leukemic mice . | Expression in inv(16) patients . |
|---|---|---|---|---|
| Il1rl1 | Interleukin 1 receptor-like 1 | 62 | Yes | 8/60 |
| Csf2rb | Colony-stimulating factor 2 receptor, beta | 48 | Yes | 59/60 |
| Ms4a2 | Membrane-spanning 4-domains, subfamily A, member 2 | 36 | Yes | 11/60 |
| Npl | N-acetylneuraminate pyruvate lyase | 24 | Yes | 17/55 |
| Prnp | Prion protein | 20 | Yes | 46/46 |
| Flot2 | Flotilin 2 | 17 | Yes | 54/60 |
| Gata2 | GATA-binding protein 2 | 17 | Yes | 55/60 |
| Adcy7 | Adenylate cyclase 7 | 15 | Yes | 46/60 |
| Pfkp | Phosphofructokinase, platelet | 15 | Yes | 53/60 |
| Gpc4 | Glypican 4 | 14 | No | 4/60 |
| Tpd52l1 | Tumor protein D52-like 1 | 14 | No | 2/60 |
| Slc41a3 | Solute carrier family 41 member 3 | 13 | Yes | 29/55 |
| Chpt1 | Choline phosphotransferase 1 | 13 | No | 54/55 |
| Slc29a1 | Solute carrier family 29, member a1 | 13 | Yes | 45/60 |
| Col5a1 | Collagen, type V, alpha 1 | 12 | Yes | 1/60 |
| Wnt2 | Wingless-related MMTV integration site 2 | 11 | No | 4/60 |
| Fabp7 | Fatty acid–binding protein 7, brain | 11 | No | 0/60 |
| Padi3 | Peptidly arginine deiminase, type III | 9 | No | 0/41 |
| Spns2 | Spinster homolog 2 (Drosophila) | 9 | No | 6/51 |
| Rnf128 | Ring finger protein 128 | 9 | Yes | 0/55 |
| Gene symbol . | Gene name . | Fold change in Cbfb-MYH embryos . | Expressed in Cbfb-MYH leukemic mice . | Expression in inv(16) patients . |
|---|---|---|---|---|
| Il1rl1 | Interleukin 1 receptor-like 1 | 62 | Yes | 8/60 |
| Csf2rb | Colony-stimulating factor 2 receptor, beta | 48 | Yes | 59/60 |
| Ms4a2 | Membrane-spanning 4-domains, subfamily A, member 2 | 36 | Yes | 11/60 |
| Npl | N-acetylneuraminate pyruvate lyase | 24 | Yes | 17/55 |
| Prnp | Prion protein | 20 | Yes | 46/46 |
| Flot2 | Flotilin 2 | 17 | Yes | 54/60 |
| Gata2 | GATA-binding protein 2 | 17 | Yes | 55/60 |
| Adcy7 | Adenylate cyclase 7 | 15 | Yes | 46/60 |
| Pfkp | Phosphofructokinase, platelet | 15 | Yes | 53/60 |
| Gpc4 | Glypican 4 | 14 | No | 4/60 |
| Tpd52l1 | Tumor protein D52-like 1 | 14 | No | 2/60 |
| Slc41a3 | Solute carrier family 41 member 3 | 13 | Yes | 29/55 |
| Chpt1 | Choline phosphotransferase 1 | 13 | No | 54/55 |
| Slc29a1 | Solute carrier family 29, member a1 | 13 | Yes | 45/60 |
| Col5a1 | Collagen, type V, alpha 1 | 12 | Yes | 1/60 |
| Wnt2 | Wingless-related MMTV integration site 2 | 11 | No | 4/60 |
| Fabp7 | Fatty acid–binding protein 7, brain | 11 | No | 0/60 |
| Padi3 | Peptidly arginine deiminase, type III | 9 | No | 0/41 |
| Spns2 | Spinster homolog 2 (Drosophila) | 9 | No | 6/51 |
| Rnf128 | Ring finger protein 128 | 9 | Yes | 0/55 |
The 20 genes with human homologs and the greatest fold change in expression by microarray analysis in the blood of Cbfb+/MYH11 but not Cbfb−/− embryos compared with blood from wild-type littermates are listed. These genes were also examined for expression in leukemic cells from mice expressing Cbfb-MYH11 as determined from microarray data. Expression in inv(16) AML patient samples was determined using published gene expression data.26-30 These data are presented as a ratio of the number of patient samples expressing a given gene over the total number of inv(16) AML samples with available expression data for that gene.