Distribution of human and murine MC proteases among MC subclasses
| Species . | MC subclass . | Tryptases* . | Chymases . | MC-CPA . |
|---|---|---|---|---|
| Human | MCT | α | ||
| β (I, II, III) | ||||
| MCTC | α | CMA1 | MC-CPA | |
| β (I, II, III) | ||||
| Mouse | MMC | mMCP-1 | ||
| mMCP-2 | ||||
| CTMC | mMCP-6 | mMCP-4 | MC-CPA | |
| mMCP-7 | mMCP-5 | |||
| mMCP-9† |
| Species . | MC subclass . | Tryptases* . | Chymases . | MC-CPA . |
|---|---|---|---|---|
| Human | MCT | α | ||
| β (I, II, III) | ||||
| MCTC | α | CMA1 | MC-CPA | |
| β (I, II, III) | ||||
| Mouse | MMC | mMCP-1 | ||
| mMCP-2 | ||||
| CTMC | mMCP-6 | mMCP-4 | MC-CPA | |
| mMCP-7 | mMCP-5 | |||
| mMCP-9† |
MC indicates mast cell; MMC, mucosal mast cell; CTMC, connective tissue mast cell; mMCP, mouse mast cell protease; and CPA, carboxypeptidase A.
Refers to tetrameric, secreted tryptases. Various MC populations express a number of other trypsin-like proteases.6-8
Preferentially expressed in uterine mast cells.18