Designation, chromosomal location, and primary substrate specificities of major human and murine MC proteases
| Protein designation . | Gene name . | Chromosomal location . | Primary substrate specificity* . |
|---|---|---|---|
| Chymase (human) | CMA1 | 14q11.2 | Chymotrypsin-like (aromatic amino acid) |
| mMCP-1 | Mcpt1 | 14C1/2 | Chymotrypsin-like (aromatic amino acid) |
| mMCP-2 | Mcpt2 | 14C1/2 | Unknown (low enzymatic activity) |
| mMCP-4 | Mcpt4 | 14C1/2 | Chymotrypsin-like (aromatic amino acid) |
| mMCP-5 | Cma1/Mcpt5 | 14C1/2 | Elastase-like (Val/Ala/Ile) |
| MC-CPA (human) | CPA3 | 3q24 | CPA-like (aromatic amino acid); exopeptidase |
| MC-CPA (mouse) | Cpa3 | 3A3 | CPA-like (aromatic amino acid); exopeptidase |
| Tryptase βII/βIII (human) | TPSAB1 | 16p13.3 | Trypsin-like (Arg/Lys) |
| Tryptase αI/βI (human) | TPSA1 | 16p13.3 | Trypsin-like (Arg/Lys) |
| mMCP-6 | Mcpt6 | 17A3.3 | Trypsin-like (Arg/Lys) |
| mMCP-7 | Tpsab1 | 17A3.3 | Trypsin-like (Arg/Lys) |
| Protein designation . | Gene name . | Chromosomal location . | Primary substrate specificity* . |
|---|---|---|---|
| Chymase (human) | CMA1 | 14q11.2 | Chymotrypsin-like (aromatic amino acid) |
| mMCP-1 | Mcpt1 | 14C1/2 | Chymotrypsin-like (aromatic amino acid) |
| mMCP-2 | Mcpt2 | 14C1/2 | Unknown (low enzymatic activity) |
| mMCP-4 | Mcpt4 | 14C1/2 | Chymotrypsin-like (aromatic amino acid) |
| mMCP-5 | Cma1/Mcpt5 | 14C1/2 | Elastase-like (Val/Ala/Ile) |
| MC-CPA (human) | CPA3 | 3q24 | CPA-like (aromatic amino acid); exopeptidase |
| MC-CPA (mouse) | Cpa3 | 3A3 | CPA-like (aromatic amino acid); exopeptidase |
| Tryptase βII/βIII (human) | TPSAB1 | 16p13.3 | Trypsin-like (Arg/Lys) |
| Tryptase αI/βI (human) | TPSA1 | 16p13.3 | Trypsin-like (Arg/Lys) |
| mMCP-6 | Mcpt6 | 17A3.3 | Trypsin-like (Arg/Lys) |
| mMCP-7 | Tpsab1 | 17A3.3 | Trypsin-like (Arg/Lys) |
MC indicates mast cell; mMCP, mouse mast cell protease; and CPA, carboxypeptidase A.
Refers to the preferred amino acid residue N-terminal of the cleavage site (P1 position).