Differentially expressed genes in the molecularly defined ALK+ ALCL
| . | Genes in classifier . | Other differentially expressed genes . |
|---|---|---|
| Classical ALCL markers | ALK, CD30, MUC1 | |
| Immunoregulatory cytokines | IL26, IL31RA, IL9, IL1R2 | IL20, IL22, IL2RA, IL1RAP, IL1R1 |
| TH17-cell–associated | IL17A, IL17F, RORγ | |
| Proliferation-related | CCNA1, AGT, PDE4DIP, UPK1B | CDC27, FGF5, FOSL2 |
| Genes noted in other tumors | RRAD, RARα, NRCAM, TMEM158, CA12 | VCAN, TNFRSF12A |
| STAT3 regulation targets | SERPINB3, SERPINB4 | SOCS1, SOCS3 |
| Cytotoxic molecules | PRF1, GZMB | |
| Immunosuppressive response | LILRA3 |
| . | Genes in classifier . | Other differentially expressed genes . |
|---|---|---|
| Classical ALCL markers | ALK, CD30, MUC1 | |
| Immunoregulatory cytokines | IL26, IL31RA, IL9, IL1R2 | IL20, IL22, IL2RA, IL1RAP, IL1R1 |
| TH17-cell–associated | IL17A, IL17F, RORγ | |
| Proliferation-related | CCNA1, AGT, PDE4DIP, UPK1B | CDC27, FGF5, FOSL2 |
| Genes noted in other tumors | RRAD, RARα, NRCAM, TMEM158, CA12 | VCAN, TNFRSF12A |
| STAT3 regulation targets | SERPINB3, SERPINB4 | SOCS1, SOCS3 |
| Cytotoxic molecules | PRF1, GZMB | |
| Immunosuppressive response | LILRA3 |
For abbreviations, see Table 2.
Only representative genes are included in each signature.