Differentially expressed genes in the molecularly defined ATLL
| . | Genes in classifier . | Other differentially expressed genes . |
|---|---|---|
| TCR signaling components and costimulatory/inhibitory molecules | TCRα, TCRβ, CD1ϵ, CTLA4, CD99, TRAC | ICOS, CD28, CD1B, CD1C, CD6, LAT, FYN, FYB |
| T-cell activation or differentiation | TNFRSF25(DR3), CD27, LEF1, NFATC1 | IL2RA (CD25), IL4R, IL18R1, IL23R,IL12RB2, MAL, IL4R, GATA3 |
| Proinflammatory | CCR4, CCL13, IL23R | IL6, IL6ST, CCL26 |
| Melanoma-associated | MAGEA4, MAGEA9, MAGEA4B | MAGEB1, MAGEA3 |
| Immune modulatory enzymes | PGDS (hematopoietic) | PTGER4, PTGER3 |
| B cells | AICDA, MTA3 | |
| Previously published genes associated with ATLL | IKZF2, RGS13, PTHLH, RGS13, CADM1(TSLC1) | TCF4 |
| HTLV-1 Tax target | c-Myc, TIAM1, PDE8B, DOK5, ARNT2, UST, PGDSMYCN, PDE8B, CEBPA, RGS13, PTHLH, SMARCA2, CD99, CADM1(TSLC1),CCR4, RGS2, SPINK2, RORA | IL2RA, CFLAR |
| Treg cell chemoattractant | CCL22, CCL20, CCL17 | |
| Cytotoxic molecules | TIA1 |
| . | Genes in classifier . | Other differentially expressed genes . |
|---|---|---|
| TCR signaling components and costimulatory/inhibitory molecules | TCRα, TCRβ, CD1ϵ, CTLA4, CD99, TRAC | ICOS, CD28, CD1B, CD1C, CD6, LAT, FYN, FYB |
| T-cell activation or differentiation | TNFRSF25(DR3), CD27, LEF1, NFATC1 | IL2RA (CD25), IL4R, IL18R1, IL23R,IL12RB2, MAL, IL4R, GATA3 |
| Proinflammatory | CCR4, CCL13, IL23R | IL6, IL6ST, CCL26 |
| Melanoma-associated | MAGEA4, MAGEA9, MAGEA4B | MAGEB1, MAGEA3 |
| Immune modulatory enzymes | PGDS (hematopoietic) | PTGER4, PTGER3 |
| B cells | AICDA, MTA3 | |
| Previously published genes associated with ATLL | IKZF2, RGS13, PTHLH, RGS13, CADM1(TSLC1) | TCF4 |
| HTLV-1 Tax target | c-Myc, TIAM1, PDE8B, DOK5, ARNT2, UST, PGDSMYCN, PDE8B, CEBPA, RGS13, PTHLH, SMARCA2, CD99, CADM1(TSLC1),CCR4, RGS2, SPINK2, RORA | IL2RA, CFLAR |
| Treg cell chemoattractant | CCL22, CCL20, CCL17 | |
| Cytotoxic molecules | TIA1 |
For abbreviations, see Table 2.
Only up-regulated representative genes are included in each signature.