Outcome measures in AML
| Category . | Definition . |
|---|---|
| Overall survival | Defined for all patients of a trial; measured from the date of entry into a study to the date of death from any cause; patients not known to have died at last follow-up are censored on the date they were last known to be alive |
| Relapse-free survival* | Defined only for patients achieving CR or CRi‡; measured from the date of achievement of a remission until the date of relapse or death from any cause; patients not known to have relapsed or died at last follow-up are censored on the date they were last examined |
| Event-free survival | Defined for all patients of a trial; measured from the date of entry into a study to the date of induction treatment failure, or relapse from CR or CRi,‡ or death from any cause; patients not known to have any of these events are censored on the date they were last examined |
| Cumulative incidence of relapse (CIR)† | Defined for all patients achieving CR or CRi‡ measured from the date of achievement of a remission until the date of relapse; patients not known to have relapsed are censored on the date they were last examined; patients who died without relapse are counted as a competing cause of failure |
| Category . | Definition . |
|---|---|
| Overall survival | Defined for all patients of a trial; measured from the date of entry into a study to the date of death from any cause; patients not known to have died at last follow-up are censored on the date they were last known to be alive |
| Relapse-free survival* | Defined only for patients achieving CR or CRi‡; measured from the date of achievement of a remission until the date of relapse or death from any cause; patients not known to have relapsed or died at last follow-up are censored on the date they were last examined |
| Event-free survival | Defined for all patients of a trial; measured from the date of entry into a study to the date of induction treatment failure, or relapse from CR or CRi,‡ or death from any cause; patients not known to have any of these events are censored on the date they were last examined |
| Cumulative incidence of relapse (CIR)† | Defined for all patients achieving CR or CRi‡ measured from the date of achievement of a remission until the date of relapse; patients not known to have relapsed are censored on the date they were last examined; patients who died without relapse are counted as a competing cause of failure |
Relapse-free and disease-free survival have been used with the same definition
It is important to provide estimates of cumulative incidence of death (CID) as well, since just considering the results of CIR may be misleading if for instance CIR is lower for one group but CID is actually higher for that same group.
In studies where the criterion CRi is used, relapse-free survival should be defined for all patients achieving CR or CRi; for event-free survival, relapse should be considered from CR and CRi.