Laboratory characteristics and clinical manifestations of patients with APS
| Patient no. . | Sex . | Age, y . | Disease . | Laboratory characteristics . | Clinical manifestations, site (no. of episodes) . | Treatment . | |||
|---|---|---|---|---|---|---|---|---|---|
| aCL IgG . | Anti-β2GPI . | LAC . | Thrombocytopenia . | ||||||
| 1 | F | 43 | PAPS | 1199* | 1358* | No | No | Superficial vein thrombosis (1), livedo reticularis, stroke | Acenocoumarol, acetylsalicylic acid |
| 2 | M | 48 | PAPS | 1100 | 945 | Yes | No | Deep vein thrombosis, autoimmune hemolytic anemia | Acenocoumarol |
| 3 | M | 43 | PAPS | 554 | 603 | No | Yes | Deep vein thrombosis (3) | Acenocoumarol, acetylsalicylic acid |
| 4 | F | 27 | PAPS | 770 | 820 | No | No | Deep vein thrombosis (4), stroke-cerebellum infarct | Acenocoumarol, acetylsalicylic acid |
| 5 | M | 29 | PAPS | 489 | 325 | Yes | No | Peripheral arterial occlusion events (2), left lower extremity | Acenocoumarol, acetylsalicylic acid |
| 6 | M | 40 | APS/SLE | 1008 | 964 | No | No | Stroke (1), Libman-Sacks endocarditis | Acenocoumarol, acetylsalicylic acid, prednisolone, hydroxychloroquine sulphate |
| 7 | F | 39 | PAPS | 785 | 973 | No | No | Brain infarcts in MRI, spontaneous abortions (2, after 10th week of gestation) | Acetylsalicylic acid |
| 8 | F | 45 | APS/SLE | 774 | 826 | No | Yes (<25 000) | Spontaneous abortions(3, after 10th week of gestation) | Acetylsalicylic acid, prednisolone |
| 9 | F | 67 | PAPS | 1348 | 1384 | Yes | No | Spontaneous abortion (1, after 10th week of gestation), superficial/deep vein thrombosis (1/1, left lower extremity), brain microinfarcts | Acenocoumarol, acetylsalicylic acid |
| 10 | M | 28 | PAPS | 345 | 598 | Yes | Yes | Budd-Chiari, livedo reticularis | Acetylsalicylic acid, Warfarin sodium |
| Patient no. . | Sex . | Age, y . | Disease . | Laboratory characteristics . | Clinical manifestations, site (no. of episodes) . | Treatment . | |||
|---|---|---|---|---|---|---|---|---|---|
| aCL IgG . | Anti-β2GPI . | LAC . | Thrombocytopenia . | ||||||
| 1 | F | 43 | PAPS | 1199* | 1358* | No | No | Superficial vein thrombosis (1), livedo reticularis, stroke | Acenocoumarol, acetylsalicylic acid |
| 2 | M | 48 | PAPS | 1100 | 945 | Yes | No | Deep vein thrombosis, autoimmune hemolytic anemia | Acenocoumarol |
| 3 | M | 43 | PAPS | 554 | 603 | No | Yes | Deep vein thrombosis (3) | Acenocoumarol, acetylsalicylic acid |
| 4 | F | 27 | PAPS | 770 | 820 | No | No | Deep vein thrombosis (4), stroke-cerebellum infarct | Acenocoumarol, acetylsalicylic acid |
| 5 | M | 29 | PAPS | 489 | 325 | Yes | No | Peripheral arterial occlusion events (2), left lower extremity | Acenocoumarol, acetylsalicylic acid |
| 6 | M | 40 | APS/SLE | 1008 | 964 | No | No | Stroke (1), Libman-Sacks endocarditis | Acenocoumarol, acetylsalicylic acid, prednisolone, hydroxychloroquine sulphate |
| 7 | F | 39 | PAPS | 785 | 973 | No | No | Brain infarcts in MRI, spontaneous abortions (2, after 10th week of gestation) | Acetylsalicylic acid |
| 8 | F | 45 | APS/SLE | 774 | 826 | No | Yes (<25 000) | Spontaneous abortions(3, after 10th week of gestation) | Acetylsalicylic acid, prednisolone |
| 9 | F | 67 | PAPS | 1348 | 1384 | Yes | No | Spontaneous abortion (1, after 10th week of gestation), superficial/deep vein thrombosis (1/1, left lower extremity), brain microinfarcts | Acenocoumarol, acetylsalicylic acid |
| 10 | M | 28 | PAPS | 345 | 598 | Yes | Yes | Budd-Chiari, livedo reticularis | Acetylsalicylic acid, Warfarin sodium |
LAC indicates lupus anticoagulant; PAPS, primary antiphospholipid syndrome; SLE, systemic lupus erythematosus; and MRI, magnetic resonance imaging.
Absorbance at 410 nm, cutoff (mean ± 3 SD), 52 ± 43.68.