Table 1
Cytogenetic risk categories in 200 patients with primary myelofibrosis
| Patient group | No. of patients (median survival, mo) | Cytogenetic risk group | Median survival, mo* | |
|---|---|---|---|---|
| All patients | 200 (74) | |||
| Sole del(20q) | 21 (112) |  | ||
| Sole del(13q) | 8 (105) | Favorable | ||
| Sole +9 | 6 (not reached) | 113 | ||
| Normal | 117 (80) | Normal | ||
| Other abnormalities | ||||
| Sole −5/del(5q) | 1 (not reached) |  | ||
| Sole −7/7q− | 2 (56) | |||
| 20q− plus one other abnormality | ||||
| 13q− plus one other abnormality | 2 (58) | |||
| +9 plus one other abnormality | 1 (22) | Others | 46 | |
| +8 plus one other abnormality | 1 (4) | |||
| Others with 2 abnormalities† | 7 (29) | |||
| Others with sole abnormalities‡ | 11 (46) | |||
| Complex karyotype | 13 (34) |  | Unfavorable | |
| Sole +8 | 7 (28) | 34 | ||
| Patient group | No. of patients (median survival, mo) | Cytogenetic risk group | Median survival, mo* | |
|---|---|---|---|---|
| All patients | 200 (74) | |||
| Sole del(20q) | 21 (112) | | ||
| Sole del(13q) | 8 (105) | Favorable | ||
| Sole +9 | 6 (not reached) | 113 | ||
| Normal | 117 (80) | Normal | ||
| Other abnormalities | ||||
| Sole −5/del(5q) | 1 (not reached) | | ||
| Sole −7/7q− | 2 (56) | |||
| 20q− plus one other abnormality | ||||
| 13q− plus one other abnormality | 2 (58) | |||
| +9 plus one other abnormality | 1 (22) | Others | 46 | |
| +8 plus one other abnormality | 1 (4) | |||
| Others with 2 abnormalities† | 7 (29) | |||
| Others with sole abnormalities‡ | 11 (46) | |||
| Complex karyotype | 13 (34) | | Unfavorable | |
| Sole +8 | 7 (28) | 34 | ||
*
P = .003, favorable versus normal versus other abnormalities versus unfavorable.
†
47,XY,t(1;9)(p10;q10),+der(1;9)(q10;p10)[14]/46,XY[6]; 46,XY,t(2;11)(p15;q23)?c[17]/46,idem,del(5)(q13q33)[3]; 46,XX,−7,+r[18]/46,XX[2]; 46,XX,−20,+mar[20]; 46,XY, 8p−,9q+; +8 and del(20q−); +1,der(1;13)[2].
‡
+19; 47,XY,+21[20]; 1q+; 46,XY,i(17q)[7]/46,XY[13]; 46,XY,inv(3)(q21q26.2)[12]; 46,XY,+1,der(1;7)(q10;p10)[7]/46,XY[13]; 46,XX,+1,der(1;7)(q10;p10)[8]/46,XX[2]; 46,XY,t(2;12)(p13;q13)?c[20]; 46,XY,add(2)(p13)[6]46,idem,+9,−21[1]/46,XY[13]; add(20)(q13.3); 46,XX,add(9)(q13)[2]/46,XX[28].