Cellular composition of the neonatal spleen after exposure to NIMA-like alloantigens
| . | Injected neonates . | Control neonates . |
|---|---|---|
| Total cells, ×108 | 1.2 ± 0.6*** | 0.8 ± 0.3 |
| CD4+, ×106 | 2.0 ± 1.0 | 1.9 ± 0.9 |
| CD8+, ×106 | 1.1 ± 0.7 | 0.6 ± 0.3 |
| F4/80+, ×107 | 3.4 ± 2.3 | 2.3 ± 2.1 |
| B220+, ×106 | 4.0 ± 0.5** | 7.8 ± 1.8 |
| CD11c+, ×105 | 8.2 ± 3.6 | 6.6 ± 3.9 |
| TER-119+, ×107 | 7.7 ± 3.0* | 5.2 ± 0.7 |
| . | Injected neonates . | Control neonates . |
|---|---|---|
| Total cells, ×108 | 1.2 ± 0.6*** | 0.8 ± 0.3 |
| CD4+, ×106 | 2.0 ± 1.0 | 1.9 ± 0.9 |
| CD8+, ×106 | 1.1 ± 0.7 | 0.6 ± 0.3 |
| F4/80+, ×107 | 3.4 ± 2.3 | 2.3 ± 2.1 |
| B220+, ×106 | 4.0 ± 0.5** | 7.8 ± 1.8 |
| CD11c+, ×105 | 8.2 ± 3.6 | 6.6 ± 3.9 |
| TER-119+, ×107 | 7.7 ± 3.0* | 5.2 ± 0.7 |
Neonates were injected with allogeneic adult donor cells as described in Figure 2, and the absolute number of T-cell and APC populations was determined. Shown are the means (± SD) of pooled data from 2 to 21 experiments. Statistical significance was determined using a 2-tailed t test. ***P < .001; **P = .03; *P = .05.