Gene methylation detected by MCAM
| Patient . | Age, y . | Time from diagnosis to relapse, mo . | FAB classification . | Karyotype at diagnosis . | Karyotype at relapse . | Genes methylated at diagnosis (%)* . | Genes methylated at relapse (%)* . | P . |
|---|---|---|---|---|---|---|---|---|
| 1 | 28 | 13 | M1 | Complex | Complex | 1228 (13.6) | 1373 (15.2) | .002 |
| 2 | 60 | 29 | M1 | Complex | Complex | 560 (6.2) | 736 (8.2) | <.001 |
| 3 | 61 | 12 | M2 | Complex | Complex | 930 (10.3) | 1163 (12.9) | <.001 |
| 4 | 46 | 9 | M1 | Diploid | Complex | 530 (5.9) | 724 (8.0) | <.001 |
| Median | 53 | 13 | 745 (8.3) | 950 (10.6) | <.001 |
| Patient . | Age, y . | Time from diagnosis to relapse, mo . | FAB classification . | Karyotype at diagnosis . | Karyotype at relapse . | Genes methylated at diagnosis (%)* . | Genes methylated at relapse (%)* . | P . |
|---|---|---|---|---|---|---|---|---|
| 1 | 28 | 13 | M1 | Complex | Complex | 1228 (13.6) | 1373 (15.2) | .002 |
| 2 | 60 | 29 | M1 | Complex | Complex | 560 (6.2) | 736 (8.2) | <.001 |
| 3 | 61 | 12 | M2 | Complex | Complex | 930 (10.3) | 1163 (12.9) | <.001 |
| 4 | 46 | 9 | M1 | Diploid | Complex | 530 (5.9) | 724 (8.0) | <.001 |
| Median | 53 | 13 | 745 (8.3) | 950 (10.6) | <.001 |
A total of 9008 autosomal genes was analyzed. Chi-square test.