Engraftment of purified ALL cells in primary mice*
Patient ID . | Cell dose . | Immune phenotype of sorted cells . | Engraftment level (%) . | Posttransplantation survival, wk . |
---|---|---|---|---|
L754 | 100 000 | CD20low | 63 | 24 |
40 | 32 | |||
7 | 33 | |||
CD20high | 59 | 23 | ||
21 | 29 | |||
WB51 | 62 400 | CD20low | 23 | 15 |
28 | 15 | |||
32 | 15 | |||
10 800 | CD20high | 37 | 16 | |
39 | 19 | |||
4000 | CD19low | 25 | 19 | |
28 | 20 | |||
31 200 | CD19high | 27 | 15 | |
38 | 16 | |||
43 | 16 | |||
35 | 17 | |||
No. 1 | 100 000 | CD34highCD19low | 6 | 26 |
76 | 32 | |||
No. 9 | 30 000 | CD34highCD19low | 93 | 7 |
99 | 16 | |||
200 000-250 000 | CD34highCD19high | 97 | 7 | |
47 | 13 | |||
96 | 14 | |||
99 | 15 | |||
No. 12 | 10 000 | CD34highCD19high | 73 | 15 |
CD34lowCD19high | 56 | 15 |
Patient ID . | Cell dose . | Immune phenotype of sorted cells . | Engraftment level (%) . | Posttransplantation survival, wk . |
---|---|---|---|---|
L754 | 100 000 | CD20low | 63 | 24 |
40 | 32 | |||
7 | 33 | |||
CD20high | 59 | 23 | ||
21 | 29 | |||
WB51 | 62 400 | CD20low | 23 | 15 |
28 | 15 | |||
32 | 15 | |||
10 800 | CD20high | 37 | 16 | |
39 | 19 | |||
4000 | CD19low | 25 | 19 | |
28 | 20 | |||
31 200 | CD19high | 27 | 15 | |
38 | 16 | |||
43 | 16 | |||
35 | 17 | |||
No. 1 | 100 000 | CD34highCD19low | 6 | 26 |
76 | 32 | |||
No. 9 | 30 000 | CD34highCD19low | 93 | 7 |
99 | 16 | |||
200 000-250 000 | CD34highCD19high | 97 | 7 | |
47 | 13 | |||
96 | 14 | |||
99 | 15 | |||
No. 12 | 10 000 | CD34highCD19high | 73 | 15 |
CD34lowCD19high | 56 | 15 |
le Viseur et al6 and K. Wilson and K. Rehe, unpublished data, March 2009.