VAF347-induced gene expression changes in maturing DCs
| Induction . | Inhibition . | ||||
|---|---|---|---|---|---|
| Probe set . | Gene . | Geo mean . | Probe set . | Gene . | Geo mean . |
| 201110_s_at | Thbs-1 | 188 | 202431_s_at | MYC | 0.26 |
| 201860_s_at | PLAT | 28.6 | 204533_at | CXCL10 | 0.27 |
| 220745_at | IL-19 | 25.1 | 210873_x_at | ARP3 | 0.28 |
| 229354_at | AhRR | 20.3 | 205692_s_at | CD38 | 0.31 |
| 219752_at | Rasal1 | 19.8 | 229053_at | Synaptotagmin XVII | 0.31 |
| 223567_at | Sema6B | 16.6 | 212279_at | MAC30 | 0.33 |
| 213725_x_at | LOC283824 | 12.4 | 1556499_s_at | unknown | 0.34 |
| 206569_at | IL-24 | 10.6 | 240287_at | unknown | 0.35 |
| 204072_s_at | 13cDNA73 | 8.4 | 210367_s_at | PTGES | 0.35 |
| 202434_s_at | Cyp1B1 | 8.3 | 204439_at | IFI44L | 0.35 |
| 228648_at | LRG1 | 8.1 | 211144_x_at | CD3G | 0.38 |
| 204311_at | ATP1B2 | 8.0 | 205207_at | IL-6 | 0.38 |
| 207674_at | CD89 | 7.7 | 225646_at | Cathepsin C | 0.38 |
| 230323_s_at | LOC120224 | 6.2 | 201416_at | SOX4 | 0.38 |
| 212665_at | TiPARP | 6.0 | 212226_s_at | PPAP2B | 0.39 |
| Induction . | Inhibition . | ||||
|---|---|---|---|---|---|
| Probe set . | Gene . | Geo mean . | Probe set . | Gene . | Geo mean . |
| 201110_s_at | Thbs-1 | 188 | 202431_s_at | MYC | 0.26 |
| 201860_s_at | PLAT | 28.6 | 204533_at | CXCL10 | 0.27 |
| 220745_at | IL-19 | 25.1 | 210873_x_at | ARP3 | 0.28 |
| 229354_at | AhRR | 20.3 | 205692_s_at | CD38 | 0.31 |
| 219752_at | Rasal1 | 19.8 | 229053_at | Synaptotagmin XVII | 0.31 |
| 223567_at | Sema6B | 16.6 | 212279_at | MAC30 | 0.33 |
| 213725_x_at | LOC283824 | 12.4 | 1556499_s_at | unknown | 0.34 |
| 206569_at | IL-24 | 10.6 | 240287_at | unknown | 0.35 |
| 204072_s_at | 13cDNA73 | 8.4 | 210367_s_at | PTGES | 0.35 |
| 202434_s_at | Cyp1B1 | 8.3 | 204439_at | IFI44L | 0.35 |
| 228648_at | LRG1 | 8.1 | 211144_x_at | CD3G | 0.38 |
| 204311_at | ATP1B2 | 8.0 | 205207_at | IL-6 | 0.38 |
| 207674_at | CD89 | 7.7 | 225646_at | Cathepsin C | 0.38 |
| 230323_s_at | LOC120224 | 6.2 | 201416_at | SOX4 | 0.38 |
| 212665_at | TiPARP | 6.0 | 212226_s_at | PPAP2B | 0.39 |
Monocyte-derived DCs were matured with anti-CD40 mAb in the absence or presence of 50 nM VAF347 for 8 hours. The geometric mean is shown representing the mean ratio of expression levels in VAF347 treated versus untreated samples using two different donors. The top 15 genes are shown.