Table 4

Values for growth inhibition, MTX influx and FPGS activity assays

Cell line/antifolateZD1694, IC50, nMZD9331, IC50, nMMTX, IC50, nMMTX influx, %FPGS activity, %
CCRF-CEM WT 6.06 ± 0.42 28.6 ± 2.3 25.7 ± 2.1 100 100 
CEM-MTXR5> 300 000 13.9 ± 1.7 23.1 ± 2 50 ± 5 0.8 ± 0.2 
CEM-MTXR10 110.1 ± 9.8 40.8 ± 4.1 28.2 ± 2.9 916 + 6 1.2 ± 0.4 
Cell line/antifolateZD1694, IC50, nMZD9331, IC50, nMMTX, IC50, nMMTX influx, %FPGS activity, %
CCRF-CEM WT 6.06 ± 0.42 28.6 ± 2.3 25.7 ± 2.1 100 100 
CEM-MTXR5> 300 000 13.9 ± 1.7 23.1 ± 2 50 ± 5 0.8 ± 0.2 
CEM-MTXR10 110.1 ± 9.8 40.8 ± 4.1 28.2 ± 2.9 916 + 6 1.2 ± 0.4