Values for growth inhibition, MTX influx and FPGS activity assays
Cell line/antifolate . | ZD1694, IC50, nM . | ZD9331, IC50, nM . | MTX, IC50, nM . | MTX influx, % . | FPGS activity, % . |
---|---|---|---|---|---|
CCRF-CEM WT | 6.06 ± 0.42 | 28.6 ± 2.3 | 25.7 ± 2.1 | 100 | 100 |
CEM-MTXR5P | > 300 000 | 13.9 ± 1.7 | 23.1 ± 2 | 50 ± 5 | 0.8 ± 0.2 |
CEM-MTXR10 | 110.1 ± 9.8 | 40.8 ± 4.1 | 28.2 ± 2.9 | 916 + 6 | 1.2 ± 0.4 |
Cell line/antifolate . | ZD1694, IC50, nM . | ZD9331, IC50, nM . | MTX, IC50, nM . | MTX influx, % . | FPGS activity, % . |
---|---|---|---|---|---|
CCRF-CEM WT | 6.06 ± 0.42 | 28.6 ± 2.3 | 25.7 ± 2.1 | 100 | 100 |
CEM-MTXR5P | > 300 000 | 13.9 ± 1.7 | 23.1 ± 2 | 50 ± 5 | 0.8 ± 0.2 |
CEM-MTXR10 | 110.1 ± 9.8 | 40.8 ± 4.1 | 28.2 ± 2.9 | 916 + 6 | 1.2 ± 0.4 |