Quantitative trait loci associated with survival, spleen weight, and WBC count
| QTL . | Peak map location (1 LPR CI) . | Closest SNP . | Model . | LPR . | R2 . | a (SE) . | d (SE) . |
|---|---|---|---|---|---|---|---|
| Mleu1.1 | 42.837 (39-46) | rs13476036 | +ENU | 3.94* | 0.125 | −0.51 (0.17)† | 0.62 (0.20)† |
| Mleu2.1 | 47.000 (37-55.3) | rs3669077 | −ENU | 2.53‡ | 0.082 | 0.56 (0.15)† | −0.28 (0.20) |
| Mleu11.1 | 54.044 (50-57) | rs13481161 | +ENU | 2.48‡ | 0.081 | −0.10 (0.13) | −0.64 (0.19)† |
| Mleu19.1 | 24.989 (14-46) | rs3655407 | +ENU | 2.99‡ | 0.096 | 0.45 (0.12)† | 0.13 (0.19) |
| MleuX.1 | 59.634 (49-ter) | rs13484113 | −ENU | 2.26‡ | 0.055 | 0.27 (0.10)† | — |
| Spl6.1 | 65.000 (53-ter) | rs13479087 | Interact | 2.62‡ | 0.036 | −0.17 (0.09) | 0.18 (0.11) |
| Spl6.1 | 65.000 (53-ter) | rs13479087 | +ENU | 1.82 | 0.060 | 0.18 (0.07)† | −0.15 (0.07) |
| Spl6.1 | 65.000 (53-ter) | rs13479087 | −ENU | 1.05 | 0.035 | −0.17 (0.10) | 0.18 (0.10) |
| Spl7.1 | 11.000 (0-20) | rs6239372 | Covariate | 3.13‡ | 0.042 | −0.20 (0.07)† | 0.13 (0.08) |
| Spl11.1 | 1.000 (0–6) | rs13480834 | −ENU | 4.24* | 0.135 | 0.38 (0.09)† | −0.20 (0.13) |
| Spl11.2 | 42.310 (37-54) | rs6384104 | +ENU | 2.47‡ | 0.081 | −0.15 (0.07)† | 0.14 (0.07)† |
| Spl16.1 | 16.505 (7-31) | rs4167843 | Interact | 2.48‡ | 0.034 | 0.13 (0.08) | 0.29 (0.11)† |
| Spl16.1 | 16.505 (7-31) | rs4167843 | +ENU | 1.20 | 0.041 | −0.14 (0.07)† | −0.12 (0.10) |
| Spl16.1 | 16.505 (7-31) | rs4167843 | −ENU | 1.47 | 0.049 | 0.13 (0.10) | 0.29 (0.13)† |
| Wbc1.1 | 24.000 (17-31) | rs6206420 | +ENU | 3.30‡ | 0.129 | −0.69 (0.20)† | −0.27 (0.27) |
| Wbc15.1 | 23.879 (16-34) | rs13482609 | +ENU | 2.75‡ | 0.109 | 0.68 (0.19)† | 0.00 (0.25) |
| Wbc19.1 | 47.000 (36-ter) | rs3718687 | Covariate | 2.85‡ | 0.042 | 0.43 (0.13)† | 0.21 (0.18) |
| QTL . | Peak map location (1 LPR CI) . | Closest SNP . | Model . | LPR . | R2 . | a (SE) . | d (SE) . |
|---|---|---|---|---|---|---|---|
| Mleu1.1 | 42.837 (39-46) | rs13476036 | +ENU | 3.94* | 0.125 | −0.51 (0.17)† | 0.62 (0.20)† |
| Mleu2.1 | 47.000 (37-55.3) | rs3669077 | −ENU | 2.53‡ | 0.082 | 0.56 (0.15)† | −0.28 (0.20) |
| Mleu11.1 | 54.044 (50-57) | rs13481161 | +ENU | 2.48‡ | 0.081 | −0.10 (0.13) | −0.64 (0.19)† |
| Mleu19.1 | 24.989 (14-46) | rs3655407 | +ENU | 2.99‡ | 0.096 | 0.45 (0.12)† | 0.13 (0.19) |
| MleuX.1 | 59.634 (49-ter) | rs13484113 | −ENU | 2.26‡ | 0.055 | 0.27 (0.10)† | — |
| Spl6.1 | 65.000 (53-ter) | rs13479087 | Interact | 2.62‡ | 0.036 | −0.17 (0.09) | 0.18 (0.11) |
| Spl6.1 | 65.000 (53-ter) | rs13479087 | +ENU | 1.82 | 0.060 | 0.18 (0.07)† | −0.15 (0.07) |
| Spl6.1 | 65.000 (53-ter) | rs13479087 | −ENU | 1.05 | 0.035 | −0.17 (0.10) | 0.18 (0.10) |
| Spl7.1 | 11.000 (0-20) | rs6239372 | Covariate | 3.13‡ | 0.042 | −0.20 (0.07)† | 0.13 (0.08) |
| Spl11.1 | 1.000 (0–6) | rs13480834 | −ENU | 4.24* | 0.135 | 0.38 (0.09)† | −0.20 (0.13) |
| Spl11.2 | 42.310 (37-54) | rs6384104 | +ENU | 2.47‡ | 0.081 | −0.15 (0.07)† | 0.14 (0.07)† |
| Spl16.1 | 16.505 (7-31) | rs4167843 | Interact | 2.48‡ | 0.034 | 0.13 (0.08) | 0.29 (0.11)† |
| Spl16.1 | 16.505 (7-31) | rs4167843 | +ENU | 1.20 | 0.041 | −0.14 (0.07)† | −0.12 (0.10) |
| Spl16.1 | 16.505 (7-31) | rs4167843 | −ENU | 1.47 | 0.049 | 0.13 (0.10) | 0.29 (0.13)† |
| Wbc1.1 | 24.000 (17-31) | rs6206420 | +ENU | 3.30‡ | 0.129 | −0.69 (0.20)† | −0.27 (0.27) |
| Wbc15.1 | 23.879 (16-34) | rs13482609 | +ENU | 2.75‡ | 0.109 | 0.68 (0.19)† | 0.00 (0.25) |
| Wbc19.1 | 47.000 (36-ter) | rs3718687 | Covariate | 2.85‡ | 0.042 | 0.43 (0.13)† | 0.21 (0.18) |
QTL locations and gene effects are shown for survival (MleuX.Y, where X is the chromosome and Y is the number along the chromosome), spleen weight (SplX.Y), and white blood cell count (WbcX.Y).
LPR CI indicates likelihood probability ratio confidence interval; R2, proportion of variance for the model; a, gene effects for the additive genotypic value; d, gene effects for the dominance genotypic value; SE, standard error of the estimate.
Significant at the genomewide threshold.
Significant at P = .05.
Significant at the chromosome-wide threshold.