Differential counts comparing nonleukemic and leukemic PR+ F2 mice
| . | −ENU . | +ENU . | ||
|---|---|---|---|---|
| Nonleukemic, n = 6 . | Leukemic, n = 6 . | Nonleukemic, n = 4 . | Leukemic, n = 6 . | |
| Peripheral blood | ||||
| Myeloid precursors | ||||
| Early | 0 (0) | 6 (1-15)* | 0 (0) | 3 (0-7) |
| Mid | 1.67 (0-3) | 25 (6-44)† | 4.25 (1-7) | 24.83 (14-36)† |
| Late | 36.5 (26-67) | 38.33 (16-85) | 44 (31-63) | 55 (22-72) |
| Lymphocytes | 56.67 (28-67) | 25.67 (3-46)† | 47 (25-61) | 13.33 (5-31)† |
| Erythroid precursors | 0.17 (0-1) | 2.5 (0-8) | 1.25 (0-2) | 2 (0-6) |
| Eosinophils | 1.33 (0-3) | 0.67 (0-3) | 0.25 (0-1) | 0.17 (0-1) |
| Monocytes | 3.67 (2-6) | 1.83 (0-3) | 3.25 (1-5) | 1.67 (0-4) |
| Bone marrow | ||||
| Myeloid precursors | ||||
| Early | 5 (3-7) | 33.29 (16-50)‡ | 5 (4-7) | 26.17 (7-64) |
| Mid | 11.5 (5-20) | 12.57 (5-22) | 15.25 (8-20) | 17.17 (10-33) |
| Late | 55.5 (45-64) | 34.14 (11-58)* | 54.25 (33-62) | 32.83 (10-65) |
| Lymphocytes | 8.5 (5-12) | 2.86 (1-5)‡ | 7.25 (4-15) | 2.5 (1-4) |
| Erythroid precursors | 17 (14-22) | 12.43 (5-21) | 15 (6-21) | 20.17 (9-33) |
| Eosinophils | 2.17 (0-7) | 4.43 (0-25) | 2.5 (0-4) | 1 (0-4) |
| Monocytes | 0.33 (0-2) | 0.29 (0-2) | 0.75 (0-2) | 0.17 (0-1) |
| . | −ENU . | +ENU . | ||
|---|---|---|---|---|
| Nonleukemic, n = 6 . | Leukemic, n = 6 . | Nonleukemic, n = 4 . | Leukemic, n = 6 . | |
| Peripheral blood | ||||
| Myeloid precursors | ||||
| Early | 0 (0) | 6 (1-15)* | 0 (0) | 3 (0-7) |
| Mid | 1.67 (0-3) | 25 (6-44)† | 4.25 (1-7) | 24.83 (14-36)† |
| Late | 36.5 (26-67) | 38.33 (16-85) | 44 (31-63) | 55 (22-72) |
| Lymphocytes | 56.67 (28-67) | 25.67 (3-46)† | 47 (25-61) | 13.33 (5-31)† |
| Erythroid precursors | 0.17 (0-1) | 2.5 (0-8) | 1.25 (0-2) | 2 (0-6) |
| Eosinophils | 1.33 (0-3) | 0.67 (0-3) | 0.25 (0-1) | 0.17 (0-1) |
| Monocytes | 3.67 (2-6) | 1.83 (0-3) | 3.25 (1-5) | 1.67 (0-4) |
| Bone marrow | ||||
| Myeloid precursors | ||||
| Early | 5 (3-7) | 33.29 (16-50)‡ | 5 (4-7) | 26.17 (7-64) |
| Mid | 11.5 (5-20) | 12.57 (5-22) | 15.25 (8-20) | 17.17 (10-33) |
| Late | 55.5 (45-64) | 34.14 (11-58)* | 54.25 (33-62) | 32.83 (10-65) |
| Lymphocytes | 8.5 (5-12) | 2.86 (1-5)‡ | 7.25 (4-15) | 2.5 (1-4) |
| Erythroid precursors | 17 (14-22) | 12.43 (5-21) | 15 (6-21) | 20.17 (9-33) |
| Eosinophils | 2.17 (0-7) | 4.43 (0-25) | 2.5 (0-4) | 1 (0-4) |
| Monocytes | 0.33 (0-2) | 0.29 (0-2) | 0.75 (0-2) | 0.17 (0-1) |
Data are mean (range) counts per 100 nucleated cells.
Early indicates blasts and promyelocytes; Mid, myelocytes and metamyelocytes; Late, bands and neutrophils.
P < .05 for 2-tailed unpaired t tests of nonleukemic versus leukemic counts.
P < .01 for 2-tailed unpaired t tests of nonleukemic versus leukemic counts.
P < .001 for 2-tailed unpaired t tests of nonleukemic versus leukemic counts.