Table 4

Clonal evolution and survival from time of new cytogenetic change

Cytogenetics at reassessmentn (%)Median survival, mo
Remained diploid 53 (73) 36 
Favorable abnormalities 5 (7) 31 
Unfavorable abnormalities 6 (8) 18 
Abnormal chromosome 17 6 (8) 
Other abnormalities 3 (4) 21 
Cytogenetics at reassessmentn (%)Median survival, mo
Remained diploid 53 (73) 36 
Favorable abnormalities 5 (7) 31 
Unfavorable abnormalities 6 (8) 18 
Abnormal chromosome 17 6 (8) 
Other abnormalities 3 (4) 21 

Patients who had repeat cytogenetics testing performed for progressive disease or blast phase transformation were excluded from this analysis. Patients who had more than 1 repeat cytogenetics testing during follow-up were classified according to the last marrow examination to show karyotypic progression.

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