Table 3

Univariate and multivariate analyses of prognostic factors

Prognostic factorPatients tested at initial diagnosis
Patients tested beyond initial diagnosis
Univariate
Multivariate
Univariate
Multivariate
Median survival, moPHazard ratioPMedian survival, moPHazard ratioP
Age         
    Less than 65 years 57 .009 1.6 .05 46 .001 2.2 .002 
    65 years or more 29    20    
Performance status         
    0 57 < .001 2.6 < .001 34 .008 — NS 
    1 or more 23    21    
Hemoglobin         
    10 g/dL or more 60 < .001 2.3 .001 54 < .001 — NS 
    Less than 10 g/dL or TD 26    21    
WCC         
    4-30 × 109/L 52 .04 — NS 29 .04 1.8 .03 
    Less than 4/more than 30 × 109/L 29    16    
Platelet count         
    100 or more × 109/L 53 < .001 2.3 .003 40 < .001 2.6 < .001 
    Less than 100 × 109/L 16    13    
Monocytes         
    Less than 1.0 × 109/L 50 .05 — NS — NS — NS 
    1.0 or more × 109/L 32        
Peripheral blasts         
    Less than 2% 46 .004 — NS 34 .05 1.9 .007 
    2% or more 24    21    
Diploid or nonunfavorable CG 48 .002 3.5 .003 29 < .001 2.6 .004 
Unfavorable or very unfavorable CG 6    7    
Prognostic factorPatients tested at initial diagnosis
Patients tested beyond initial diagnosis
Univariate
Multivariate
Univariate
Multivariate
Median survival, moPHazard ratioPMedian survival, moPHazard ratioP
Age         
    Less than 65 years 57 .009 1.6 .05 46 .001 2.2 .002 
    65 years or more 29    20    
Performance status         
    0 57 < .001 2.6 < .001 34 .008 — NS 
    1 or more 23    21    
Hemoglobin         
    10 g/dL or more 60 < .001 2.3 .001 54 < .001 — NS 
    Less than 10 g/dL or TD 26    21    
WCC         
    4-30 × 109/L 52 .04 — NS 29 .04 1.8 .03 
    Less than 4/more than 30 × 109/L 29    16    
Platelet count         
    100 or more × 109/L 53 < .001 2.3 .003 40 < .001 2.6 < .001 
    Less than 100 × 109/L 16    13    
Monocytes         
    Less than 1.0 × 109/L 50 .05 — NS — NS — NS 
    1.0 or more × 109/L 32        
Peripheral blasts         
    Less than 2% 46 .004 — NS 34 .05 1.9 .007 
    2% or more 24    21    
Diploid or nonunfavorable CG 48 .002 3.5 .003 29 < .001 2.6 .004 
Unfavorable or very unfavorable CG 6    7    

Adverse cytogenetics were independently associated with inferior survival in both patients tested at diagnosis, and those tested beyond initial diagnosis.

TD indicates transfusion dependent; WCC, white cell count; NS, not significant; and CG, cytogenetics.

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