Univariate and multivariate analyses of variables associated with overall and event-free survival
| Variable . | n/N (%) . | Overall survival . | Event-free survival . | ||
|---|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | ||
| Univariate | |||||
| IgA isotype* | 43/154 (28) | 1.17 (0.81-1.69) | .408 | 1.21 (0.85-1.74) | .293 |
| λ light chain | 46/153 (30) | 1.48 (1.03-2.14) | .036 | 1.43 (1.00-2.05) | .048 |
| Age ≥ 65 yr | 43/169 (25) | 1.55 (1.09-2.22) | .016 | 1.44 (1.01-2.05) | .045 |
| CRP ≥ 4 mg/L | 108/158 (68) | 1.58 (1.09-2.28) | .016 | 1.57 (1.09-2.24) | .014 |
| β2-microglobulin ≥ 3.5 mg/L | 66/160 (41) | 3.74 (2.62-5.34) | < .001 | 1.89 (1.35-2.65) | < .001 |
| Albumin < 3.5 g/dL | 35/163 (21) | 1.91 (1.29-2.81) | .001 | 1.18 (0.81-1.74) | .386 |
| Hb < 10 g/dL | 67/163 (41) | 2.28 (1.63-3.19) | < .001 | 1.69 (1.22-2.36) | .002 |
| Platelets < 150 × 109/L | 104/163 (64) | 1.50 (1.06-2.11) | .021 | 1.06 (0.76-1.47) | .743 |
| Creatinine ≥ 2.0 mg/dL | 23/162 (14) | 2.88 (1.82-4.57) | < .001 | 2.11 (1.34-3.34) | .001 |
| LDH ≥ 190 U/L | 39/160 (24) | 1.81 (1.25-2.64) | .002 | 1.42 (0.98-2.06) | .061 |
| ISS stage 1* | 84/160 (53) | 0.30 (0.21-0.42) | < .001 | 0.55 (0.40-0.77) | < .001 |
| ISS stage 2* | 37/160 (23) | 1.85 (1.26-2.71) | .002 | 1.38 (0.94-2.00) | .098 |
| ISS stage 3* | 39/160 (24) | 3.19 (2.16-4.71) | < .001 | 1.68 (1.15-2.44) | .007 |
| Cytogenetic abnormalities (CAs) | 75/161 (47) | 3.07 (2.15-4.38) | < .001 | 2.21 (1.57-3.12) | < .001 |
| Hypodiploid | 24/149 (16) | 2.49 (1.58-3.92) | < .001 | 2.25 (1.42-3.54) | < .001 |
| Deletion 13q | 38/154 (25) | 2.76 (1.85-4.10) | < .001 | 2.30 (1.56-3.39) | < .001 |
| Deletion 1p | 11/154 (7) | 2.20 (1.18-4.10) | .014 | 2.03 (1.09-3.80) | .026 |
| Deletion 17p | 11/154 (7) | 1.93 (1.00-3.73) | .049 | 1.94 (1.04-3.65) | .039 |
| At least 2 prior transplants | 89/169 (53) | 1.49 (1.07-2.06) | .017 | 1.33 (0.97-1.82) | .078 |
| Multivariate (any CA) | |||||
| λ light chain | 39/136 (29) | 1.61 (1.08-2.42) | .021 | 1.53 (1.04-2.25) | .030 |
| Age ≥ 65 years | 31/136 (23) | 2.03 (1.32-3.11) | .001 | NA | NA |
| Cytogenetic abnormalities (CAs) | 61/136 (45) | 2.91 (1.95-4.35) | < .001 | 2.23 (1.53-3.26) | < .001 |
| β2-microglobulin ≥ 3.5 mg/L | 49/136 (36) | 3.20 (2.15-4.76) | < .001 | NA | NA |
| Multivariate (CA subgroups) | |||||
| Age ≥ 65 yr | 30/130 (23) | 1.92 (1.24-2.98) | .003 | NA | NA |
| Creatinine ≥ 2.0 mg/dL | 17/130 (13) | 2.00 (1.09-3.70) | .026 | 1.88 (1.10-3.21) | .022 |
| β2-microglobulin ≥ 3.5 mg/L | 45/130 (35) | 2.47 (1.55-3.92) | < .001 | NA | NA |
| Deletion 13 | 28/130 (22) | 2.18 (1.35-3.52) | .002 | 2.17 (1.39-3.40) | < .001 |
| Hb < 10 g/dL | 51/130 (39) | 1.63 (1.08-2.47) | .021 | NA | NA |
| At least 2 prior transplants | 68/130 (52) | 1.64 (1.11-2.42) | .012 | NA | NA |
| Variable . | n/N (%) . | Overall survival . | Event-free survival . | ||
|---|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | ||
| Univariate | |||||
| IgA isotype* | 43/154 (28) | 1.17 (0.81-1.69) | .408 | 1.21 (0.85-1.74) | .293 |
| λ light chain | 46/153 (30) | 1.48 (1.03-2.14) | .036 | 1.43 (1.00-2.05) | .048 |
| Age ≥ 65 yr | 43/169 (25) | 1.55 (1.09-2.22) | .016 | 1.44 (1.01-2.05) | .045 |
| CRP ≥ 4 mg/L | 108/158 (68) | 1.58 (1.09-2.28) | .016 | 1.57 (1.09-2.24) | .014 |
| β2-microglobulin ≥ 3.5 mg/L | 66/160 (41) | 3.74 (2.62-5.34) | < .001 | 1.89 (1.35-2.65) | < .001 |
| Albumin < 3.5 g/dL | 35/163 (21) | 1.91 (1.29-2.81) | .001 | 1.18 (0.81-1.74) | .386 |
| Hb < 10 g/dL | 67/163 (41) | 2.28 (1.63-3.19) | < .001 | 1.69 (1.22-2.36) | .002 |
| Platelets < 150 × 109/L | 104/163 (64) | 1.50 (1.06-2.11) | .021 | 1.06 (0.76-1.47) | .743 |
| Creatinine ≥ 2.0 mg/dL | 23/162 (14) | 2.88 (1.82-4.57) | < .001 | 2.11 (1.34-3.34) | .001 |
| LDH ≥ 190 U/L | 39/160 (24) | 1.81 (1.25-2.64) | .002 | 1.42 (0.98-2.06) | .061 |
| ISS stage 1* | 84/160 (53) | 0.30 (0.21-0.42) | < .001 | 0.55 (0.40-0.77) | < .001 |
| ISS stage 2* | 37/160 (23) | 1.85 (1.26-2.71) | .002 | 1.38 (0.94-2.00) | .098 |
| ISS stage 3* | 39/160 (24) | 3.19 (2.16-4.71) | < .001 | 1.68 (1.15-2.44) | .007 |
| Cytogenetic abnormalities (CAs) | 75/161 (47) | 3.07 (2.15-4.38) | < .001 | 2.21 (1.57-3.12) | < .001 |
| Hypodiploid | 24/149 (16) | 2.49 (1.58-3.92) | < .001 | 2.25 (1.42-3.54) | < .001 |
| Deletion 13q | 38/154 (25) | 2.76 (1.85-4.10) | < .001 | 2.30 (1.56-3.39) | < .001 |
| Deletion 1p | 11/154 (7) | 2.20 (1.18-4.10) | .014 | 2.03 (1.09-3.80) | .026 |
| Deletion 17p | 11/154 (7) | 1.93 (1.00-3.73) | .049 | 1.94 (1.04-3.65) | .039 |
| At least 2 prior transplants | 89/169 (53) | 1.49 (1.07-2.06) | .017 | 1.33 (0.97-1.82) | .078 |
| Multivariate (any CA) | |||||
| λ light chain | 39/136 (29) | 1.61 (1.08-2.42) | .021 | 1.53 (1.04-2.25) | .030 |
| Age ≥ 65 years | 31/136 (23) | 2.03 (1.32-3.11) | .001 | NA | NA |
| Cytogenetic abnormalities (CAs) | 61/136 (45) | 2.91 (1.95-4.35) | < .001 | 2.23 (1.53-3.26) | < .001 |
| β2-microglobulin ≥ 3.5 mg/L | 49/136 (36) | 3.20 (2.15-4.76) | < .001 | NA | NA |
| Multivariate (CA subgroups) | |||||
| Age ≥ 65 yr | 30/130 (23) | 1.92 (1.24-2.98) | .003 | NA | NA |
| Creatinine ≥ 2.0 mg/dL | 17/130 (13) | 2.00 (1.09-3.70) | .026 | 1.88 (1.10-3.21) | .022 |
| β2-microglobulin ≥ 3.5 mg/L | 45/130 (35) | 2.47 (1.55-3.92) | < .001 | NA | NA |
| Deletion 13 | 28/130 (22) | 2.18 (1.35-3.52) | .002 | 2.17 (1.39-3.40) | < .001 |
| Hb < 10 g/dL | 51/130 (39) | 1.63 (1.08-2.47) | .021 | NA | NA |
| At least 2 prior transplants | 68/130 (52) | 1.64 (1.11-2.42) | .012 | NA | NA |
NA indicates not applicable.
Variable not included for multivariate selection.