Patients studied for cure of allergy after hematopoietic stem cell transplantation
| Source, demographics; disease . | Donor . | Allergy status*† . | Follow-up, mo . | GVHD . | IS‡ . | Chimerism . | Cure§ documented conclusively? . | ||
|---|---|---|---|---|---|---|---|---|---|
| Donor . | Pretransplantation recipient . | Posttransplantation recipient‡ . | |||||||
| 1. Wahn et al,38 5 yo male; Fanconi anemia | HLA-identical sib | CM: None; T-IgE: 185 kU/mL; A-IgE <0.35 kU/L (latex). | CM: anaphylaxis after contact with latex; T-IgE >2000 IU/mL;A-IgE >100 kU/L (latex). | CM: None; T-IgE gradually dropped from 88 IU/L at 1 mo to ≤9 IU/mL 12-20 mo posttransplantation;A-IgE gradually dropped from 18.60 kU/L at 1 mo to <0.35 kU/L 14 and 20 mo posttransplantation (latex). SPT for latex negative 20 mo posttransplantation. | 20 | Acute | 12 | Complete | Yes |
| 2. Koharazawa et al,39 33 yo male; CML | Unrelated | CM: None; T-IgE: NR;A-IgE: NR | CM: eczema; T-IgE: 3130mg/dL;A-IgE: NR | CM: none; T-IgE: 212mg/dL;A-IgE: NR | 48 | Acute | 14 | Complete | No¶ |
| 3. Hourihane et al,40 12 yo male; CID | Unrelated | CM: NR; T-IgE: NR;A-IgE: NR | CM: eczema, angioedema, and urticaria after ingesting peanuts, peas, or lentils; T-IgE: 2533 IU/mL;A-IgE: 23.1 kU/L (peanuts) | CM: none. Nonallergic to peanuts by oral challenge;T-IgE: dropped from 100 IU/mL at 2 months to 40 IU/mL 17 months posttransplantation;A-IgE <0.35 kU/L (peanuts) and negative SPT for peanuts at 17 months posttransplantation | 24 | Acute | 14 | Complete | Yes |
| Source, demographics; disease . | Donor . | Allergy status*† . | Follow-up, mo . | GVHD . | IS‡ . | Chimerism . | Cure§ documented conclusively? . | ||
|---|---|---|---|---|---|---|---|---|---|
| Donor . | Pretransplantation recipient . | Posttransplantation recipient‡ . | |||||||
| 1. Wahn et al,38 5 yo male; Fanconi anemia | HLA-identical sib | CM: None; T-IgE: 185 kU/mL; A-IgE <0.35 kU/L (latex). | CM: anaphylaxis after contact with latex; T-IgE >2000 IU/mL;A-IgE >100 kU/L (latex). | CM: None; T-IgE gradually dropped from 88 IU/L at 1 mo to ≤9 IU/mL 12-20 mo posttransplantation;A-IgE gradually dropped from 18.60 kU/L at 1 mo to <0.35 kU/L 14 and 20 mo posttransplantation (latex). SPT for latex negative 20 mo posttransplantation. | 20 | Acute | 12 | Complete | Yes |
| 2. Koharazawa et al,39 33 yo male; CML | Unrelated | CM: None; T-IgE: NR;A-IgE: NR | CM: eczema; T-IgE: 3130mg/dL;A-IgE: NR | CM: none; T-IgE: 212mg/dL;A-IgE: NR | 48 | Acute | 14 | Complete | No¶ |
| 3. Hourihane et al,40 12 yo male; CID | Unrelated | CM: NR; T-IgE: NR;A-IgE: NR | CM: eczema, angioedema, and urticaria after ingesting peanuts, peas, or lentils; T-IgE: 2533 IU/mL;A-IgE: 23.1 kU/L (peanuts) | CM: none. Nonallergic to peanuts by oral challenge;T-IgE: dropped from 100 IU/mL at 2 months to 40 IU/mL 17 months posttransplantation;A-IgE <0.35 kU/L (peanuts) and negative SPT for peanuts at 17 months posttransplantation | 24 | Acute | 14 | Complete | Yes |
NR indicates not reported; yo, year old; RAST, radioallergosorbent test; CML, chronic myelogenous leukemia; CID, combined immunodeficiency; CM, clinical manifestation; T-IgE, total IgE; and A-IgE, allergen-specific IgE.
Total serum IgE (suggestive but not diagnostic of allergy), typical reference value, less than 300 IU/mL.
Allergen-specific IgE (diagnostic of allergic disease if present in a person with clinical manifestations of allergic disease). Typical reference value is less than 0.35 kU/L or RAST score 0 (scale 0-4).
Duration of pharmacologic immunosuppression
Long-term remission.
Reason for the inconclusiveness of cure in patient 2: recipient pretransplantation allergen-specific IgE was not reported.