Patients studied for transfer of allergy after hematopoietic stem cell transplantation
Source, patient no., demographics, disease . | Donor . | Allergy status*† . | Follow-up . | GVHD . | IS§ . | Chimerism . | Transfer documented conclusively? . | ||
---|---|---|---|---|---|---|---|---|---|
Donor . | Pretransplantation recipient . | Posttransplantation recipient‡ . | |||||||
Tucker et al29 | |||||||||
1. 9 yo male; ALL | HLA-ident. sib | CM: eczema, rhinitis, asthma and angioedema/vomiting. Allergic to egg, fish, beans, and peanuts (by history) T-IgE: 1879 U/mLA-IgE: RAST 2 (egg), 4 (cat), 4 (DM), 3 (peanut) | CM: noneT-IgE: 78 U/mLA-IgE: RAST 0 (egg), 0 (cat), 0 (DM), 0 (peanut) | CM: angioedema/vomiting. Allergic to egg, ?fish, beans, and ?nuts (by history) T-IgE: 910 U/mLA-IgE: RAST 2 (egg), 4 (cat), 3 (DM), 3 (peanut) | 25 mo | Acute | 6 mo | NR | Yes |
Saarinen27 | |||||||||
2. 8 yo female; AML | HLA-ident. sib | CM: rhinitisT-IgE: NRA-IgE: RAST 3 (cat). SPT positive for cat, dog and DM | CM: eczema “Allergic to egg” by history T-IgE: NRA-Ig: NR | CM: indeterminate (frequent respiratory infections) T-IgE: 1300 U/mLA-IgE: RAST 2 (cat). SPT positive for cat, dog and DM. | 3 y | Acute | 9 mo | NR | No** |
Walker et al30 | |||||||||
3. 2 yo female; Morquio syndrome | HLA-MM sib | CM: noneT-IgE: 200 IU/mLA-IgE: RAST 1 (egg), 2 (cow's milk) | CM: noneT-IgE: 41 IU/mLA-IgE: RAST 0 (egg), 0 (cow's milk) | CM: noneT-IgE: >1000 IU/mLA-IgE: RAST 1 (egg), 0 (cow's milk) | 26 mo | NR | NR | NR | No†† |
4. 9 yo male; ALL | HLA-ident. sib | CM: eczema, asthma, angioedema/vomiting after ingesting nuts, beans, egg or fish. T-IgE = 840 IU/mLA-IgE = RAST 2 (cat), 1 (peanut), 3 (egg) | CM: noneT-IgE: 9 IU/mLA-IgE: RAST 0 (cat), 0 (peanut), 0 (egg). | CM: angioedema/vomiting after ingesting beans, egg or fish. T-IgE: 295 IU/mLA-IgE: RAST 3 (cat), 0 (peanut), 2 (egg) | 13 mo | NR | NR | NR | Yes |
5. 4 yo female; SAA | HLA-ident. sib | CM: rhinitis T-IgE: 900 IU/mLA-IgE: RAST 3 (Timothy) | CM: none. T-IgE: <5 IU/mLA-IgE: RAST 0 (Timothy) | CM: rhinitis. T-IgE: 200 IU/mLA-IgE: RAST 3 (Timothy) | 24 mo | NR | NR | NR | Yes |
6. 12 yo female; SAA | HLA-ident. sib | CM: “Intolerant” to penicillinT-IgE: 315 IU/mLA-IgE: RAST “positive” (penicillin V) | CM: none (treated with penicillin without problems) T-IgE: >1000 IU/mLA-IgE: RAST “negative” (penicillin V) | CM: rash when treated with azlocillin T-IgE: 80 IU/mLA-IgE: RAST “positive” (penicillin V) | 3 mo | NR | NR | NR | Yes |
Bellou et al24 | |||||||||
7. 5 yo male; ALL | HLA-ident. sib | CM: eczema, asthmaT-IgE: 285 IU/LA-IgE: 1.23 kU/L (egg). SPT positive for egg | CM: noneT-IgE: NRA-IgE: NR | CM: eczemaT-IgE: 6400 IU/LA-IgE: 65.00 kU/L (egg). SPT positive for egg | 32 mo | Acute | 9 mo | Complete | No‡‡ |
Lucke et al25 | |||||||||
8. 31 yo female; BLL | HLA-ident. sib | CM: eczema. Allergic to rubber by history and patch test T-IgE: NRA-IgE: NR | CM: none T-IgE: NRA-IgE: NR | CM: eczema. Allergic to rubber by history and patch test T-IgE: NRA-IgE: NR | 8 mo | Acute | 8 mo | Complete | No§§ |
Rietz et al26 | |||||||||
9. 18 yo female; AML | HLA-ident. sib | CM: asthma T-IgE: NRA-IgE: NR | CM: none T-IgE: NRA-IgE: NR | CM: asthma T-IgE: NRA-IgE: NR | 32 mo | NR | NR | NR | No¶¶ |
10. 43 yo female; AML | HLA-ident. sib | CM: Asthma T-IgE: NRA-IgE: NR | CM: None T-IgE: NRA-IgE: NR | CM: Asthma T-IgE: NRA-IgE: NR | 6 mo | NR | NR | NR | No¶¶ |
Yong et al31 | |||||||||
11. 41 yo female; NHL | HLA-ident. sib | CM: eczema, rhinitis and asthma. “Allergic to banana” by historyT-IgE: NRA-IgE: 32.70 kU/L (DM), 1.73 kU/L (dog), <0.35 kU/L (banana). SPT positive for DM, dog and pollens | CM; noneT-IgE: 33 kU/LA-IgE <0.35 kU/L (banana), NR for DM or dog | CM: eczema, rhinitis, urticaria/diarrhea after ingesting bananaT-IgE: 173 kU/LA-IgE: 1.45 kU/L (banana), NR for DM or dog. SPT positive for DM, dog and pollens | 14 mo | Acute | 90 d | Mixed (at 7 mo), then complete (after DLI) | No‖‖ |
Agosty et al32 and Hallstrand et al33 | |||||||||
12. 14 yo male; ALL | HLA-ident. sib | CM: moderate rhinitis and mild asthma T-IgE: NRA-IgE: RAST 4 (DF). SPT positive for DF | CM: noneT-IgE: 17 U/mLA-IgE: RAST 0 (DF). SPT negative for DF | CM: moderate rhinitis T-IgE: normal rangeA-IgE: RAST 3 (DF). SPT positive for DF | 1 y | None | 6 mo | Complete | Yes |
Same (later follow-up) | CM: mild asthma and moderate rhinitis. T-IgE: 731 U/mLA-IgE: RAST 1 (DF) | 16 y‖ | None | 6 mo | Complete | Yes | |||
13. 43 yo male CML | HLA-ident. sib | CM: moderate rhinitis and mild asthma T-IgE: NRA-IgE: RAST 2 (DF). SPT positive for DF | CM: moderate rhinitisT-IgE: <5U/mLA-IgE: RAST 0 (DF). SPT negative for DF | CM: severe rhinitisT-IgE: normal rangeA-IgE: RAST 2 (DF). SPT positive for DF | 1 y | None | 6 mo | Complete | No*** |
Same (later follow-up) | CM: moderate rhinitis T-IgE: 839 U/mLA-IgE: RAST 4 (DF) | 16 y‖ | None | 6 mo | Complete | No*** | |||
14. 38 yrs; Female; CML | HLA-ident. sib | CM: mild rhinitis. T-IgE: NRA-IgE: RAST 0 (DF) | CM: noneT-IgE: 13U/mLA-IgE: RAST 0 (DF) | CM: moderate rhinitis, moderate asthmaT-IgE: in normal rangeA-IgE: RAST 0 (DF) | 1 yr‖ | None | 6 mo | Complete | No††† |
Same (later follow-up) | CM: severe asthma and moderate rhinitis T-IgE: 36 U/mLA-IgE: RAST 0 (DF) | 16 yr‖ | Chronic | ≤2yr | Complete | No††† | |||
15. 47 yo male; CML | HLA-ident. sib | CM: mild rhinitis T-IgE: NRA-IgE: RAST 3 (DF). SPT positive for DF | CM: none. T-IgE: 7 U/mLA-IgE: RAST 0 (DF). SPT negative for DF. | CM: mild rhinitis T-IgE: normal rangeA-IgE: RAST 0 (DF). SPT negative for DF | 1 y¶ | Acute | 1 yr | Complete | No††† |
Same (later follow-up) | CM: moderate rhinitis and moderate asthma T-IgE: 8 U/mLA-IgE: RAST 0 (DF) | 14 y‖ | Chronic | ≤2 yr | Complete | No††† | |||
16. 17 yo female; AML | HLA-ident. sib | CM: moderate rhinitis, moderate asthma. T-IgE: NRA-IgE: RAST 0 (DF). | CM: moderate rhinitis, moderate asthma T-IgE: 7 U/mLA-IgE: RAST 0 (DF). | CM: moderate rhinitis, severe asthma T-IgE: normal rangeA-IgE: RAST 0 (DF) | 1 y | None | 6 mo | Complete | No*** |
Same (later follow-up) | CM: moderate rhinitis, moderate asthma T-IgE: 271 U/mLA-IgE: RAST 0 (DF). | 15 y‖ | None | 6 mo | Complete | No*** | |||
17. 18 yo female; AML | HLA-ident. sib | CM: severe asthma T-IgE: NRA-IgE: RAST 2 (DF). SPT positive for DF. | CM: none T-IgE: NRA-IgE: RAST 0 (DF). SPT negative for DF. | CM: mild rhinitis T-IgE: normal rangeA-IgE: RAST 0 (DF). SPT positive for DF | 1 y | None | 6 mo | Complete | No††† |
18. 20 yo female; CML | HLA-ident. sib | CM: moderate rhinitis T-IgE: NRA-IgE: RAST 2 (DF). SPT positive for DF. | CM: none T-IgE: NRA-IgE: RAST 0 (DF). SPT positive for DF. | CM: mild rhinitis T-IgE: normal rangeA-IgE: RAST 0 (DF). SPT negative for DF. | 1 y | None | 6 mo | Complete | No††† |
Source, patient no., demographics, disease . | Donor . | Allergy status*† . | Follow-up . | GVHD . | IS§ . | Chimerism . | Transfer documented conclusively? . | ||
---|---|---|---|---|---|---|---|---|---|
Donor . | Pretransplantation recipient . | Posttransplantation recipient‡ . | |||||||
Tucker et al29 | |||||||||
1. 9 yo male; ALL | HLA-ident. sib | CM: eczema, rhinitis, asthma and angioedema/vomiting. Allergic to egg, fish, beans, and peanuts (by history) T-IgE: 1879 U/mLA-IgE: RAST 2 (egg), 4 (cat), 4 (DM), 3 (peanut) | CM: noneT-IgE: 78 U/mLA-IgE: RAST 0 (egg), 0 (cat), 0 (DM), 0 (peanut) | CM: angioedema/vomiting. Allergic to egg, ?fish, beans, and ?nuts (by history) T-IgE: 910 U/mLA-IgE: RAST 2 (egg), 4 (cat), 3 (DM), 3 (peanut) | 25 mo | Acute | 6 mo | NR | Yes |
Saarinen27 | |||||||||
2. 8 yo female; AML | HLA-ident. sib | CM: rhinitisT-IgE: NRA-IgE: RAST 3 (cat). SPT positive for cat, dog and DM | CM: eczema “Allergic to egg” by history T-IgE: NRA-Ig: NR | CM: indeterminate (frequent respiratory infections) T-IgE: 1300 U/mLA-IgE: RAST 2 (cat). SPT positive for cat, dog and DM. | 3 y | Acute | 9 mo | NR | No** |
Walker et al30 | |||||||||
3. 2 yo female; Morquio syndrome | HLA-MM sib | CM: noneT-IgE: 200 IU/mLA-IgE: RAST 1 (egg), 2 (cow's milk) | CM: noneT-IgE: 41 IU/mLA-IgE: RAST 0 (egg), 0 (cow's milk) | CM: noneT-IgE: >1000 IU/mLA-IgE: RAST 1 (egg), 0 (cow's milk) | 26 mo | NR | NR | NR | No†† |
4. 9 yo male; ALL | HLA-ident. sib | CM: eczema, asthma, angioedema/vomiting after ingesting nuts, beans, egg or fish. T-IgE = 840 IU/mLA-IgE = RAST 2 (cat), 1 (peanut), 3 (egg) | CM: noneT-IgE: 9 IU/mLA-IgE: RAST 0 (cat), 0 (peanut), 0 (egg). | CM: angioedema/vomiting after ingesting beans, egg or fish. T-IgE: 295 IU/mLA-IgE: RAST 3 (cat), 0 (peanut), 2 (egg) | 13 mo | NR | NR | NR | Yes |
5. 4 yo female; SAA | HLA-ident. sib | CM: rhinitis T-IgE: 900 IU/mLA-IgE: RAST 3 (Timothy) | CM: none. T-IgE: <5 IU/mLA-IgE: RAST 0 (Timothy) | CM: rhinitis. T-IgE: 200 IU/mLA-IgE: RAST 3 (Timothy) | 24 mo | NR | NR | NR | Yes |
6. 12 yo female; SAA | HLA-ident. sib | CM: “Intolerant” to penicillinT-IgE: 315 IU/mLA-IgE: RAST “positive” (penicillin V) | CM: none (treated with penicillin without problems) T-IgE: >1000 IU/mLA-IgE: RAST “negative” (penicillin V) | CM: rash when treated with azlocillin T-IgE: 80 IU/mLA-IgE: RAST “positive” (penicillin V) | 3 mo | NR | NR | NR | Yes |
Bellou et al24 | |||||||||
7. 5 yo male; ALL | HLA-ident. sib | CM: eczema, asthmaT-IgE: 285 IU/LA-IgE: 1.23 kU/L (egg). SPT positive for egg | CM: noneT-IgE: NRA-IgE: NR | CM: eczemaT-IgE: 6400 IU/LA-IgE: 65.00 kU/L (egg). SPT positive for egg | 32 mo | Acute | 9 mo | Complete | No‡‡ |
Lucke et al25 | |||||||||
8. 31 yo female; BLL | HLA-ident. sib | CM: eczema. Allergic to rubber by history and patch test T-IgE: NRA-IgE: NR | CM: none T-IgE: NRA-IgE: NR | CM: eczema. Allergic to rubber by history and patch test T-IgE: NRA-IgE: NR | 8 mo | Acute | 8 mo | Complete | No§§ |
Rietz et al26 | |||||||||
9. 18 yo female; AML | HLA-ident. sib | CM: asthma T-IgE: NRA-IgE: NR | CM: none T-IgE: NRA-IgE: NR | CM: asthma T-IgE: NRA-IgE: NR | 32 mo | NR | NR | NR | No¶¶ |
10. 43 yo female; AML | HLA-ident. sib | CM: Asthma T-IgE: NRA-IgE: NR | CM: None T-IgE: NRA-IgE: NR | CM: Asthma T-IgE: NRA-IgE: NR | 6 mo | NR | NR | NR | No¶¶ |
Yong et al31 | |||||||||
11. 41 yo female; NHL | HLA-ident. sib | CM: eczema, rhinitis and asthma. “Allergic to banana” by historyT-IgE: NRA-IgE: 32.70 kU/L (DM), 1.73 kU/L (dog), <0.35 kU/L (banana). SPT positive for DM, dog and pollens | CM; noneT-IgE: 33 kU/LA-IgE <0.35 kU/L (banana), NR for DM or dog | CM: eczema, rhinitis, urticaria/diarrhea after ingesting bananaT-IgE: 173 kU/LA-IgE: 1.45 kU/L (banana), NR for DM or dog. SPT positive for DM, dog and pollens | 14 mo | Acute | 90 d | Mixed (at 7 mo), then complete (after DLI) | No‖‖ |
Agosty et al32 and Hallstrand et al33 | |||||||||
12. 14 yo male; ALL | HLA-ident. sib | CM: moderate rhinitis and mild asthma T-IgE: NRA-IgE: RAST 4 (DF). SPT positive for DF | CM: noneT-IgE: 17 U/mLA-IgE: RAST 0 (DF). SPT negative for DF | CM: moderate rhinitis T-IgE: normal rangeA-IgE: RAST 3 (DF). SPT positive for DF | 1 y | None | 6 mo | Complete | Yes |
Same (later follow-up) | CM: mild asthma and moderate rhinitis. T-IgE: 731 U/mLA-IgE: RAST 1 (DF) | 16 y‖ | None | 6 mo | Complete | Yes | |||
13. 43 yo male CML | HLA-ident. sib | CM: moderate rhinitis and mild asthma T-IgE: NRA-IgE: RAST 2 (DF). SPT positive for DF | CM: moderate rhinitisT-IgE: <5U/mLA-IgE: RAST 0 (DF). SPT negative for DF | CM: severe rhinitisT-IgE: normal rangeA-IgE: RAST 2 (DF). SPT positive for DF | 1 y | None | 6 mo | Complete | No*** |
Same (later follow-up) | CM: moderate rhinitis T-IgE: 839 U/mLA-IgE: RAST 4 (DF) | 16 y‖ | None | 6 mo | Complete | No*** | |||
14. 38 yrs; Female; CML | HLA-ident. sib | CM: mild rhinitis. T-IgE: NRA-IgE: RAST 0 (DF) | CM: noneT-IgE: 13U/mLA-IgE: RAST 0 (DF) | CM: moderate rhinitis, moderate asthmaT-IgE: in normal rangeA-IgE: RAST 0 (DF) | 1 yr‖ | None | 6 mo | Complete | No††† |
Same (later follow-up) | CM: severe asthma and moderate rhinitis T-IgE: 36 U/mLA-IgE: RAST 0 (DF) | 16 yr‖ | Chronic | ≤2yr | Complete | No††† | |||
15. 47 yo male; CML | HLA-ident. sib | CM: mild rhinitis T-IgE: NRA-IgE: RAST 3 (DF). SPT positive for DF | CM: none. T-IgE: 7 U/mLA-IgE: RAST 0 (DF). SPT negative for DF. | CM: mild rhinitis T-IgE: normal rangeA-IgE: RAST 0 (DF). SPT negative for DF | 1 y¶ | Acute | 1 yr | Complete | No††† |
Same (later follow-up) | CM: moderate rhinitis and moderate asthma T-IgE: 8 U/mLA-IgE: RAST 0 (DF) | 14 y‖ | Chronic | ≤2 yr | Complete | No††† | |||
16. 17 yo female; AML | HLA-ident. sib | CM: moderate rhinitis, moderate asthma. T-IgE: NRA-IgE: RAST 0 (DF). | CM: moderate rhinitis, moderate asthma T-IgE: 7 U/mLA-IgE: RAST 0 (DF). | CM: moderate rhinitis, severe asthma T-IgE: normal rangeA-IgE: RAST 0 (DF) | 1 y | None | 6 mo | Complete | No*** |
Same (later follow-up) | CM: moderate rhinitis, moderate asthma T-IgE: 271 U/mLA-IgE: RAST 0 (DF). | 15 y‖ | None | 6 mo | Complete | No*** | |||
17. 18 yo female; AML | HLA-ident. sib | CM: severe asthma T-IgE: NRA-IgE: RAST 2 (DF). SPT positive for DF. | CM: none T-IgE: NRA-IgE: RAST 0 (DF). SPT negative for DF. | CM: mild rhinitis T-IgE: normal rangeA-IgE: RAST 0 (DF). SPT positive for DF | 1 y | None | 6 mo | Complete | No††† |
18. 20 yo female; CML | HLA-ident. sib | CM: moderate rhinitis T-IgE: NRA-IgE: RAST 2 (DF). SPT positive for DF. | CM: none T-IgE: NRA-IgE: RAST 0 (DF). SPT positive for DF. | CM: mild rhinitis T-IgE: normal rangeA-IgE: RAST 0 (DF). SPT negative for DF. | 1 y | None | 6 mo | Complete | No††† |
NR indicates not reported; yo, years old; SPT, skin prick test; HLA-MM, human leukocyte antigen mismatched; DM, dust mite (species not specified); DF, Dermatophagoids farinae; DLI, donor lymphocyte infusion; RAST, radio allergosorbent test; CML, chronic myelogenous leukemia; AML, acute myelogenous leukemia; ALL, acute lymphoblastic leukemia; NHL, non-Hodgkin lymphoma; CM, clinical manifestation; T-IgE, total IgE; and A-IgE, allergen-specific IgE.
Total serum IgE (suggestive but not diagnostic of allergy), typical reference value less than 300 IU/mL.
Allergen-specific IgE (diagnostic of allergic disease if present in a person with clinical manifestations of allergic disease). Typical reference value is less than 0.35 kU/L or RAST score 0 (scale 0-4).
Allergy status evalution was done at multiple time points after transplantation, however, the data shown in the table is for the time point when most prominent allergic reactions were observed or, if the timing of the allergic symptoms was not reported, the latest posttransplantation time point available.
Duration of pharmacologic immunosuppression
Agosti et al32 : only patients for whom patient-individual data have been reported are shown here.
Hallstrand et al33 : only patients for whom patient-individual data have been reported are shown here.
Patient 2: The recipient pretransplantation had eczema, recipient allergen-specific IgE pretransplantation was not reported; and presence or absence of clinical rhinitis or asthma posttransplantation could not be determined as the recipient had frequent respiratory infection.
Patient 3: transfer of allergy but not allergic disease.
Patient7: pretransplantation allergen-specific IgE in the recipient was not studied.
Patient 8: no patch test or allergen-specific IgE result on the recipient pretransplantation was reported.
Patients 9 and 10: allergen-specific IgE was not studied.
Patient 11: the donor had elevated IgE to dog, dust mite, and pollens but not banana, but the recipient posttransplantation had elevated IgE to dog, dust mite, pollens, and banana; recipient pretransplantation levels of IgE to dog, dust mite, and pollens were unreported, but he was known to have an elevated level of IgE to banana (so the allergy to banana could be of recipient origin).
Patients 13 and 16: recipient pretransplantation had rhinitis and/or asthma.
Patients 14, 15, 17, 18: unclear whether allergic or nonallergic asthma/rhinitis was transferred; also, patient 18 had positive SPT for dust mite pretransplantation.