Telomere length measured in patients with BMF
| Subgroup . | No. of patients (families) . | No. of patients with telomeres ≤ 1st percentile (%) . | ||
|---|---|---|---|---|
| WUMC . | Referred* . | All . | ||
| DC | 1 (1) | 18 (9) | 19 (10) | 19 (100) |
| DBA | 9 (6) | 25 (22) | 34 (28) | 5 (14.7) |
| SDS | 5 (5) | 0 (0) | 5 (5) | 1 (20) |
| MDS | 14 (14) | 3 (3) | 17 (16) | 3 (17.6) |
| PNH | 23 (23) | 2 (2) | 25 (25) | 4 (16) |
| AA | 33 (32) | 24 (21) | 57 (53) | 16 (28.1) |
| IBMF | 2 (2) | 1 (1) | 3 (3) | 1 (33.3) |
| Total | 87 (83) | 73 (58) | 160 (139) | 49 (30.6) |
| Subgroup . | No. of patients (families) . | No. of patients with telomeres ≤ 1st percentile (%) . | ||
|---|---|---|---|---|
| WUMC . | Referred* . | All . | ||
| DC | 1 (1) | 18 (9) | 19 (10) | 19 (100) |
| DBA | 9 (6) | 25 (22) | 34 (28) | 5 (14.7) |
| SDS | 5 (5) | 0 (0) | 5 (5) | 1 (20) |
| MDS | 14 (14) | 3 (3) | 17 (16) | 3 (17.6) |
| PNH | 23 (23) | 2 (2) | 25 (25) | 4 (16) |
| AA | 33 (32) | 24 (21) | 57 (53) | 16 (28.1) |
| IBMF | 2 (2) | 1 (1) | 3 (3) | 1 (33.3) |
| Total | 87 (83) | 73 (58) | 160 (139) | 49 (30.6) |
WUMC indicates Washington University Medical Center; DC, dyskeratosis congenita; DBA, Diamond Blackfan syndrome; SDS, Shwachman-Diamond syndrome; MDS, myelodysplastic syndrome; PNH, paroxysmal nocturnal hemoglobinuria; AA, aplastic anemia; and IBMF, inherited bone marrow failure.
Patients enrolled through institutions outside Washington University.