Genes related to the ubiquitin cycle as identified by WEBGESTALT (but not specifically identified as immune-related) differentially regulated between matched, doubly loaded DCs and DCs loaded by any other method
| Ubiquitin metabolism . | ||||
|---|---|---|---|---|
| Gene . | Regulation . | Cohen's d . | q . | Function . |
| RFP2 | Down | 8.28 | < 0.0008 | Ubiquitin ligation |
| BIRC4 | Down | 7.74 | < 0.007 | Ubiquitin ligation |
| USP40 | Down | 7.56 | < 0.009 | Ubiquitin-dependent protein catabolism |
| EDEM1 | Down | 7.49 | < 0.00006 | Enhancer of ER protein catabolism |
| MDM4 | Down | 7.26 | < 0.0002 | Ubiquitin ligation |
| UCHL1 | Up | 7.01 | < 0.00002 | Deubiquitination |
| TRIP12 | Down | 6.89 | < 0.0003 | Ubiquitin ligation |
| USP4 | Down | 6.73 | < 0.004 | Ubiquitin-dependent protein catabolism |
| RNF44 | Down | 6.69 | < 0.002 | Transcriptional regulation |
| MAP3K7IP2 (2) | Down | 6.63 | < 0.0005 | Signal transduction |
| MAP3K1 | Down | 6.38 | < 0.0003 | Signal transduction |
| FBXL3 | Down | 5.70 | < 0.002 | Ubiquitin ligation |
| TRIM56 | Down | 5.69 | < 0.007 | Ubiquitin ligation |
| FLJ13855 | Down | 5.62 | < 0.0005 | Ubiquitin ligation |
| TRIM50B | Down | 5.44 | < 0.0002 | Ubiquitin ligation |
| UBE2B (2) | Down | 5.28 | < 0.002 | Ubiquitin ligation |
| MAR7 | Down | 5.16 | < 0.001 | Unknown |
| UBE3C | Down | 5.15 | < 0.01 | Ubiquitin ligation |
| UBE2D3 (3) | Down | 5.13 | < 0.0002 | Ubiquitin ligation |
| SENP6 | Down | 5.00 | < 0.004 | Ubiquitin-dependent protein catabolism |
| FLJ31951 | Down | 4.57 | < 0.0006 | Unknown |
| ANAPC5 | Down | 4.38 | < 0.0003 | Ubiquitin ligation |
| PARK2 | Down | 4.07 | < 0.006 | Ubiquitin ligation |
| VCPIP1 | Up | 3.82 | < 0.008 | Signal transduction |
| TRIM22 | Up | 3.74 | < 0.001 | Transcriptional regulation |
| PSMB2 | Up | 3.61 | < 0.002 | Ubiquitin-dependent protein catabolism |
| SENP8 | Up | 3.59 | < 0.007 | Ubiquitin-dependent protein catabolism |
| BIRC6 | Down | 3.25 | < 0.003 | Ubiquitin ligation |
| RNF34 | Down | 3.03 | < 0.003 | Ubiquitin ligation |
| TBL1X (3) | Down | 2.92 | < 0.0003 | Signal transduction |
| G1P2 | Up | 2.71 | < 0.0002 | IFN-inducible signal transduction |
| PRPF19 | Down | 2.66 | < 0.00003 | Ubiquitin ligation |
| KIAA0317 | Up | 2.64 | < 0.01 | Ubiquitin ligation |
| UBE2I | Down | 2.44 | < 0.004 | Ubiquitin ligation |
| C17orf27 | Down | 2.30 | < 0.003 | Ubiquitin ligation |
| CBLB (3) | Down | 2.24 | < 0.008 | Ubiquitin ligation |
| TSG101 | Up | 2.22 | < 0.002 | Transcriptional regulation |
| FBXO6 | Up | 2.12 | < 0.0006 | Generalized ubiquitination |
| USP18 | Up | 2.10 | < 0.0007 | Ubiquitin-dependent protein catabolism |
| MYLIP (2) | Down | 1.55 | < 0.004 | Ubiquitin ligation |
| Ubiquitin metabolism . | ||||
|---|---|---|---|---|
| Gene . | Regulation . | Cohen's d . | q . | Function . |
| RFP2 | Down | 8.28 | < 0.0008 | Ubiquitin ligation |
| BIRC4 | Down | 7.74 | < 0.007 | Ubiquitin ligation |
| USP40 | Down | 7.56 | < 0.009 | Ubiquitin-dependent protein catabolism |
| EDEM1 | Down | 7.49 | < 0.00006 | Enhancer of ER protein catabolism |
| MDM4 | Down | 7.26 | < 0.0002 | Ubiquitin ligation |
| UCHL1 | Up | 7.01 | < 0.00002 | Deubiquitination |
| TRIP12 | Down | 6.89 | < 0.0003 | Ubiquitin ligation |
| USP4 | Down | 6.73 | < 0.004 | Ubiquitin-dependent protein catabolism |
| RNF44 | Down | 6.69 | < 0.002 | Transcriptional regulation |
| MAP3K7IP2 (2) | Down | 6.63 | < 0.0005 | Signal transduction |
| MAP3K1 | Down | 6.38 | < 0.0003 | Signal transduction |
| FBXL3 | Down | 5.70 | < 0.002 | Ubiquitin ligation |
| TRIM56 | Down | 5.69 | < 0.007 | Ubiquitin ligation |
| FLJ13855 | Down | 5.62 | < 0.0005 | Ubiquitin ligation |
| TRIM50B | Down | 5.44 | < 0.0002 | Ubiquitin ligation |
| UBE2B (2) | Down | 5.28 | < 0.002 | Ubiquitin ligation |
| MAR7 | Down | 5.16 | < 0.001 | Unknown |
| UBE3C | Down | 5.15 | < 0.01 | Ubiquitin ligation |
| UBE2D3 (3) | Down | 5.13 | < 0.0002 | Ubiquitin ligation |
| SENP6 | Down | 5.00 | < 0.004 | Ubiquitin-dependent protein catabolism |
| FLJ31951 | Down | 4.57 | < 0.0006 | Unknown |
| ANAPC5 | Down | 4.38 | < 0.0003 | Ubiquitin ligation |
| PARK2 | Down | 4.07 | < 0.006 | Ubiquitin ligation |
| VCPIP1 | Up | 3.82 | < 0.008 | Signal transduction |
| TRIM22 | Up | 3.74 | < 0.001 | Transcriptional regulation |
| PSMB2 | Up | 3.61 | < 0.002 | Ubiquitin-dependent protein catabolism |
| SENP8 | Up | 3.59 | < 0.007 | Ubiquitin-dependent protein catabolism |
| BIRC6 | Down | 3.25 | < 0.003 | Ubiquitin ligation |
| RNF34 | Down | 3.03 | < 0.003 | Ubiquitin ligation |
| TBL1X (3) | Down | 2.92 | < 0.0003 | Signal transduction |
| G1P2 | Up | 2.71 | < 0.0002 | IFN-inducible signal transduction |
| PRPF19 | Down | 2.66 | < 0.00003 | Ubiquitin ligation |
| KIAA0317 | Up | 2.64 | < 0.01 | Ubiquitin ligation |
| UBE2I | Down | 2.44 | < 0.004 | Ubiquitin ligation |
| C17orf27 | Down | 2.30 | < 0.003 | Ubiquitin ligation |
| CBLB (3) | Down | 2.24 | < 0.008 | Ubiquitin ligation |
| TSG101 | Up | 2.22 | < 0.002 | Transcriptional regulation |
| FBXO6 | Up | 2.12 | < 0.0006 | Generalized ubiquitination |
| USP18 | Up | 2.10 | < 0.0007 | Ubiquitin-dependent protein catabolism |
| MYLIP (2) | Down | 1.55 | < 0.004 | Ubiquitin ligation |
The number of different transcripts detected is listed within parentheses next to each gene.