Effect of dietary iron on parameters of systemic iron
| Dietary iron, mg/kg diet . | Plasma iron, μg/dL . | Transferrin saturation, % . | Hb, g/dL . | Hct, % . | Liver iron, μg/g wet weight* . | Spleen iron, μg/g wet weight* . |
|---|---|---|---|---|---|---|
| 5 | 165 ± 53 | 32 ± 13 | 13 ± 1.5 | 43 ± 5 | 38 ± 5 | 120 ± 534 |
| 12 | 170 ± 17 | 45 ± 4 | 14.9 ± 1.5 | 48 ± 1 | 121 ± 29 | 465 ± 118 |
| 50 | 129 ± 26 | 35 ± 9 | 14.7 ± 0.4 | 46 ± 2 | 229 ± 36 | 727 ± 135 |
| 1000 | 167 ± 31 | 41 ± 13 | 14.7 ± 0.6 | 46 ± 2 | 552 ± 161 | 1216 ± 49 |
| Dietary iron, mg/kg diet . | Plasma iron, μg/dL . | Transferrin saturation, % . | Hb, g/dL . | Hct, % . | Liver iron, μg/g wet weight* . | Spleen iron, μg/g wet weight* . |
|---|---|---|---|---|---|---|
| 5 | 165 ± 53 | 32 ± 13 | 13 ± 1.5 | 43 ± 5 | 38 ± 5 | 120 ± 534 |
| 12 | 170 ± 17 | 45 ± 4 | 14.9 ± 1.5 | 48 ± 1 | 121 ± 29 | 465 ± 118 |
| 50 | 129 ± 26 | 35 ± 9 | 14.7 ± 0.4 | 46 ± 2 | 229 ± 36 | 727 ± 135 |
| 1000 | 167 ± 31 | 41 ± 13 | 14.7 ± 0.6 | 46 ± 2 | 552 ± 161 | 1216 ± 49 |
Data are mean and SD; n = 5. Modulation of dietary iron in C3H mice affects liver and spleen iron but does not affect plasma iron, transferrin saturation, hemoglobin, or hematocrit.
Statistically significant response to dietary iron, P < .001. Plasma iron, transferrin saturation, hemoglobin, and hematocrit were not significantly different.