Distribution of κ and λ CLL cases of the present series according to the number and type of light chain gene rearrangements
| No. of rearrangements . | No. κ-expressing . | No. λ-expressing . | Total . |
|---|---|---|---|
| One | |||
| IgK functional | 370 | 17 | 387 |
| IgL functional | 1 | 150 | 151 |
| IgK nonfunctional | 7 | 14 | 21 |
| IgL nonfunctional | 0 | 5 | 5 |
| Two | |||
| One IgK functional + one IGL functional | 6 | 27 | 33 |
| Two IgL functional | 0 | 3 | 3 |
| Two IgK nonfunctional | 0 | 1 | 1 |
| Two IgK functional | 17 | 0 | 17 |
| One IgK nonfunctional + one IgL functional | 0 | 45 | 45 |
| One IgK functional + one IgL nonfunctional | 1 | 0 | 1 |
| One IgK functional + one IgK nonfunctional | 20 | 0 | 20 |
| One IgL functional + one IgL nonfunctional | 0 | 4 | 4 |
| Three | |||
| Two IgK nonfunctional + one IgL functional | 0 | 10 | 10 |
| Two IgL functional + one IgK functional | 0 | 1 | 1 |
| Two IgK functional + one IgL functional | 0 | 1 | 1 |
| Two IgL functional + one IgK nonfunctional | 0 | 1 | 1 |
| Two IgK functional + one IgL nonfunctional | 1 | 0 | 1 |
| One IgK functional + one IgK nonfunctional + one IgL functional | 2 | 3 | 5 |
| One IgK nonfunctional + one IgL nonfunctional + one IGL functional | 0 | 1 | 1 |
| One IgK functional + one IgL nonfunctional + one IgL functional | 0 | 1 | 1 |
| Total | 425 | 284 | 709 |
| No. of rearrangements . | No. κ-expressing . | No. λ-expressing . | Total . |
|---|---|---|---|
| One | |||
| IgK functional | 370 | 17 | 387 |
| IgL functional | 1 | 150 | 151 |
| IgK nonfunctional | 7 | 14 | 21 |
| IgL nonfunctional | 0 | 5 | 5 |
| Two | |||
| One IgK functional + one IGL functional | 6 | 27 | 33 |
| Two IgL functional | 0 | 3 | 3 |
| Two IgK nonfunctional | 0 | 1 | 1 |
| Two IgK functional | 17 | 0 | 17 |
| One IgK nonfunctional + one IgL functional | 0 | 45 | 45 |
| One IgK functional + one IgL nonfunctional | 1 | 0 | 1 |
| One IgK functional + one IgK nonfunctional | 20 | 0 | 20 |
| One IgL functional + one IgL nonfunctional | 0 | 4 | 4 |
| Three | |||
| Two IgK nonfunctional + one IgL functional | 0 | 10 | 10 |
| Two IgL functional + one IgK functional | 0 | 1 | 1 |
| Two IgK functional + one IgL functional | 0 | 1 | 1 |
| Two IgL functional + one IgK nonfunctional | 0 | 1 | 1 |
| Two IgK functional + one IgL nonfunctional | 1 | 0 | 1 |
| One IgK functional + one IgK nonfunctional + one IgL functional | 2 | 3 | 5 |
| One IgK nonfunctional + one IgL nonfunctional + one IGL functional | 0 | 1 | 1 |
| One IgK functional + one IgL nonfunctional + one IgL functional | 0 | 1 | 1 |
| Total | 425 | 284 | 709 |
All calculations were performed on 709 of 725 patients with available information on the expressed light chain isotype.
IgK indicates immunoglobulin K; and IgL, immunoglobulin L. Other abbreviations are as explained in Table 2.