Best associations in warfarin-related candidate genes in the index patient population (University of Washington)
| Gene symbol/cluster* . | Genome coordinate† . | RsID . | P‡ . | Total SNPs in region . |
|---|---|---|---|---|
| VKORC1 | chr16:30955580 | rs10871454§ | 6.2 × 10−13 | 10 |
| CYP2C9(*2/*3 tag) | chr10:96715525 | rs4917639 | 9.7 × 10−5 | 1 |
| CYP2C9(*3) | chr10:96731043 | rs1057910 | 2.0 × 10−4 | 1 |
| CYP2C18/CYP2C19/CYP2C8/CYP2C9 | chr10:96454720 | rs7896133 | 3.6 × 10−5 | 66 |
| ABCB1 | chr7:87037500 | rs2235015 | 1.8 × 10−2 | 58 |
| APOE | chr19:50009030 | rs8101274 | 1.4 × 10−2 | 34 |
| CALU | chr7:128183918 | rs3778760 | 1.9 × 10−2 | 46 |
| CAR | chr1:159545301 | rs12065184 | 9.9 × 10−3 | 50 |
| CYP1A1/CYP1A2 | chr15:72929814 | rs2305668 | 1.4 × 10−1 | 26 |
| CYP2A6 | chr19:46103074 | rs8109507 | 6.5 × 10−2 | 32 |
| CYP3A4/CYP3A5 | chr7:99104254 | rs4646450 | 1.1 × 10−1 | 29 |
| EPHX1 | chr1:224132378 | rs360097 | 1.4 × 10−3 | 52 |
| F7/F10/PROZ | chr13:112818877 | rs488703 | 1.7 × 10−1 | 40 |
| F2 | chr11:46651990 | rs13448 | 4.8 × 10−2 | 17 |
| F5 | chr1:167880418 | rs10919202 | 2.6 × 10−3 | 92 |
| F9 | chrX:138359434 | rs17002122 | 1.7 × 10−2 | 37 |
| GAS6 | chr13:113538172 | rs9550270 | 1.2 × 10−1 | 29 |
| GGCX | chr2:85677762 | rs6643 | 2.4 × 10−2 | 30 |
| NQO1 | chr16:68302646 | rs1800566 | 1.7 × 10−1 | 18 |
| NR1I2 | chr3:120890093 | rs2137619 | 1.8 × 10−2 | 35 |
| ORM1/ORM2 | chr9:116072082 | rs1490740 | 3.6 × 10−3 | 102 |
| PROC | chr2:127941698 | rs7590705 | 5.7 × 10−2 | 29 |
| PROS | chr3:95221384 | rs13071953 | 8.0 × 10−2 | 13 |
| SERPINC1 | chr1:172126805 | rs16846546 | 1.5 × 10−2 | 18 |
| Gene symbol/cluster* . | Genome coordinate† . | RsID . | P‡ . | Total SNPs in region . |
|---|---|---|---|---|
| VKORC1 | chr16:30955580 | rs10871454§ | 6.2 × 10−13 | 10 |
| CYP2C9(*2/*3 tag) | chr10:96715525 | rs4917639 | 9.7 × 10−5 | 1 |
| CYP2C9(*3) | chr10:96731043 | rs1057910 | 2.0 × 10−4 | 1 |
| CYP2C18/CYP2C19/CYP2C8/CYP2C9 | chr10:96454720 | rs7896133 | 3.6 × 10−5 | 66 |
| ABCB1 | chr7:87037500 | rs2235015 | 1.8 × 10−2 | 58 |
| APOE | chr19:50009030 | rs8101274 | 1.4 × 10−2 | 34 |
| CALU | chr7:128183918 | rs3778760 | 1.9 × 10−2 | 46 |
| CAR | chr1:159545301 | rs12065184 | 9.9 × 10−3 | 50 |
| CYP1A1/CYP1A2 | chr15:72929814 | rs2305668 | 1.4 × 10−1 | 26 |
| CYP2A6 | chr19:46103074 | rs8109507 | 6.5 × 10−2 | 32 |
| CYP3A4/CYP3A5 | chr7:99104254 | rs4646450 | 1.1 × 10−1 | 29 |
| EPHX1 | chr1:224132378 | rs360097 | 1.4 × 10−3 | 52 |
| F7/F10/PROZ | chr13:112818877 | rs488703 | 1.7 × 10−1 | 40 |
| F2 | chr11:46651990 | rs13448 | 4.8 × 10−2 | 17 |
| F5 | chr1:167880418 | rs10919202 | 2.6 × 10−3 | 92 |
| F9 | chrX:138359434 | rs17002122 | 1.7 × 10−2 | 37 |
| GAS6 | chr13:113538172 | rs9550270 | 1.2 × 10−1 | 29 |
| GGCX | chr2:85677762 | rs6643 | 2.4 × 10−2 | 30 |
| NQO1 | chr16:68302646 | rs1800566 | 1.7 × 10−1 | 18 |
| NR1I2 | chr3:120890093 | rs2137619 | 1.8 × 10−2 | 35 |
| ORM1/ORM2 | chr9:116072082 | rs1490740 | 3.6 × 10−3 | 102 |
| PROC | chr2:127941698 | rs7590705 | 5.7 × 10−2 | 29 |
| PROS | chr3:95221384 | rs13071953 | 8.0 × 10−2 | 13 |
| SERPINC1 | chr1:172126805 | rs16846546 | 1.5 × 10−2 | 18 |
Candidate genes were clustered if their boundaries were within 100 kb, with the exception of CYP2C9, where specific polymorphisms are listed.
Coordinate for hg18; see http://genome.ucsc.edu.
Best P value within 100 kb of gene or gene cluster.
rs10871454 is perfectly correlated with rs9923231 (aka VKORC1 −1639) in the index population.