Top replication polymorphisms associated with stabilized warfarin dose
| rsID . | Genome coordinate* . | Index P (UW) . | Replication P (UF and Vanderbilt) . | Combined P . |
|---|---|---|---|---|
| rs9923231† | chr16:31015190 | 6.2 × 10−13 | 1.0 × 10−22 | 4.7 × 10−34 |
| rs4086116‡ | chr10:96697192 | 8.3 × 10−5 | 1.2 × 10−8 | 6.2 × 10−12 |
| rs2286461 | chr4:15572771 | 6.6 × 10−7 | 6.7 × 10−2 | 1.8 × 10−5 |
| rs10920212 | chr1:199713096 | 1.1 × 10−5 | 3.3 × 10−1 | 4.8 × 10−2 |
| rs549427 | chr11:113590069 | 1.4 × 10−5 | 7.0 × 10−1 | 2.1 × 10−3 |
| rs719473 | chr15:88799068 | 1.6 × 10−5 | 5.0 × 10−1 | 3.6 × 10−2 |
| rs11865472 | chr16:1124968 | 1.7 × 10−5 | 2.6 × 10−1§ | NA |
| rs10503266 | chr8:4475454 | 2.0 × 10−5 | 6.8 × 10−1 | 2.2 × 10−2 |
| rs1543245 | chr15:35144802 | 2.4 × 10−5 | 9.4 × 10−1 | 10.0 × 10−3 |
| rs2022212 | chr6:69588678 | 2.6 × 10−5 | 3.7 × 10−1 | 4.9 × 10−2 |
| rs3858304 | chr10:132039565 | 3.2 × 10−5 | 2.2 × 10−1 | 6.7 × 10−4 |
| rs11728293 | chr4:35677976 | 3.3 × 10−5 | 6.2 × 10−1 | 2.8 × 10−3 |
| rs16894959 | chr6:34933640 | 4.0 × 10−5 | 2.9 × 10−1 | 3.5 × 10−3 |
| rs17784218 | chr10:50435360 | 4.2 × 10−5 | 4.2 × 10−2 | 9.4 × 10−1 |
| rs10489371 | chr1:167199124 | 4.4 × 10−5 | 5.7 × 10−1 | 6.6 × 10−2 |
| rs2589949 | chr15:88756019 | 4.5 × 10−5 | 8.9 × 10−1 | 7.8 × 10−3 |
| rs1635852 | chr7:28155936 | 4.5 × 10−5 | 7.0 × 10−1 | 5.1 × 10−3 |
| rs3000802 | chr1:225675527 | 4.7 × 10−5 | 9.0 × 10−1 | 1.3 × 10−2 |
| rs12665384 | chr6:69747288 | 5.2 × 10−5 | 8.0 × 10−1 | 4.7 × 10−3 |
| rs10117842 | chr9:72631257 | 5.4 × 10−5 | 7.2 × 10−1 | 5.0 × 10−3 |
| rs2189784 | chr19:15820200 | 5.4 × 10−5 | 4.9 × 10−1 | 3.5 × 10−3 |
| rs11733360 | chr4:7478732 | 5.6 × 10−5 | 2.9 × 10−1 | 1.2 × 10−3 |
| rs2814944 | chr6:34660775 | 6.2 × 10−5 | 3.9 × 10−1 | 6.6 × 10−3 |
| rs2859720 | chr20:4602585 | 6.6 × 10−5 | 4.4 × 10−4 | 7.1 × 10−1 |
| rs1572237 | chr10:129202681 | 7.3 × 10−5 | 6.1 × 10−1 | 2.5 × 10−2 |
| rs913068 | chr20:55117490 | 7.4 × 10−5 | 3.6 × 10−1 | 2.1 × 10−3 |
| rs16991615 | chr20:5896227 | 7.5 × 10−5 | 6.3 × 10−1 | 5.6 × 10−1 |
| rsID . | Genome coordinate* . | Index P (UW) . | Replication P (UF and Vanderbilt) . | Combined P . |
|---|---|---|---|---|
| rs9923231† | chr16:31015190 | 6.2 × 10−13 | 1.0 × 10−22 | 4.7 × 10−34 |
| rs4086116‡ | chr10:96697192 | 8.3 × 10−5 | 1.2 × 10−8 | 6.2 × 10−12 |
| rs2286461 | chr4:15572771 | 6.6 × 10−7 | 6.7 × 10−2 | 1.8 × 10−5 |
| rs10920212 | chr1:199713096 | 1.1 × 10−5 | 3.3 × 10−1 | 4.8 × 10−2 |
| rs549427 | chr11:113590069 | 1.4 × 10−5 | 7.0 × 10−1 | 2.1 × 10−3 |
| rs719473 | chr15:88799068 | 1.6 × 10−5 | 5.0 × 10−1 | 3.6 × 10−2 |
| rs11865472 | chr16:1124968 | 1.7 × 10−5 | 2.6 × 10−1§ | NA |
| rs10503266 | chr8:4475454 | 2.0 × 10−5 | 6.8 × 10−1 | 2.2 × 10−2 |
| rs1543245 | chr15:35144802 | 2.4 × 10−5 | 9.4 × 10−1 | 10.0 × 10−3 |
| rs2022212 | chr6:69588678 | 2.6 × 10−5 | 3.7 × 10−1 | 4.9 × 10−2 |
| rs3858304 | chr10:132039565 | 3.2 × 10−5 | 2.2 × 10−1 | 6.7 × 10−4 |
| rs11728293 | chr4:35677976 | 3.3 × 10−5 | 6.2 × 10−1 | 2.8 × 10−3 |
| rs16894959 | chr6:34933640 | 4.0 × 10−5 | 2.9 × 10−1 | 3.5 × 10−3 |
| rs17784218 | chr10:50435360 | 4.2 × 10−5 | 4.2 × 10−2 | 9.4 × 10−1 |
| rs10489371 | chr1:167199124 | 4.4 × 10−5 | 5.7 × 10−1 | 6.6 × 10−2 |
| rs2589949 | chr15:88756019 | 4.5 × 10−5 | 8.9 × 10−1 | 7.8 × 10−3 |
| rs1635852 | chr7:28155936 | 4.5 × 10−5 | 7.0 × 10−1 | 5.1 × 10−3 |
| rs3000802 | chr1:225675527 | 4.7 × 10−5 | 9.0 × 10−1 | 1.3 × 10−2 |
| rs12665384 | chr6:69747288 | 5.2 × 10−5 | 8.0 × 10−1 | 4.7 × 10−3 |
| rs10117842 | chr9:72631257 | 5.4 × 10−5 | 7.2 × 10−1 | 5.0 × 10−3 |
| rs2189784 | chr19:15820200 | 5.4 × 10−5 | 4.9 × 10−1 | 3.5 × 10−3 |
| rs11733360 | chr4:7478732 | 5.6 × 10−5 | 2.9 × 10−1 | 1.2 × 10−3 |
| rs2814944 | chr6:34660775 | 6.2 × 10−5 | 3.9 × 10−1 | 6.6 × 10−3 |
| rs2859720 | chr20:4602585 | 6.6 × 10−5 | 4.4 × 10−4 | 7.1 × 10−1 |
| rs1572237 | chr10:129202681 | 7.3 × 10−5 | 6.1 × 10−1 | 2.5 × 10−2 |
| rs913068 | chr20:55117490 | 7.4 × 10−5 | 3.6 × 10−1 | 2.1 × 10−3 |
| rs16991615 | chr20:5896227 | 7.5 × 10−5 | 6.3 × 10−1 | 5.6 × 10−1 |
All P values are generated from univariate analysis assuming an additive genetic model.
NA indicates not applicable; UW, University of Washington; and UF, University of Florida.
Coordinate for hg18; genome.ucsc.edu.
rs9923231 (also known as VKORC1 −1639) genotypes had been previously generated for all three populations and is perfectly correlated with rs10871454 (see Table 2).
Best replicated SNP in CYP2C9 and in perfect linkage disequilibrium (r2 = 1.0; CEU HapMap) with rs4917639.
Data available from only the University of Florida (UF; see “Replication genotyping”).