Table 1 Association between warfarin... | American Society of Hematology

Table 1

Association between warfarin dose and VKORC1 −1639G>A, 1173C>T (intron 1), and 1542G>C (intron 2) in whites and blacks

Genotype	White				Black
Genotype	n	Warfarin dose (mg/wk)	P	R²	n	Warfarin dose (mg/wk)	P	R²
−1639G>A
GG	124	46 ± 17	<.001	0.28	105	47 ± 17	<.001	0.13
GA	156	33 ± 11			18	33 ± 15
AA	41	23 ± 7			2	23 ± 13
1173C>T
CC	123	45 ± 17	<.001	0.25	104	47 ± 17	<.001	0.14
CT	152	33 ± 11			18	32 ± 15
TT	42	25 ± 11			2	23 ± 13
1542G>C
GG	121	46 ± 18	<.001	0.22	63	45 ± 16	.59	0.002
GC	155	33 ± 11			50	45 ± 17
CC	45	24 ± 8			11	42 ± 23

Genotype	White				Black
Genotype	n	Warfarin dose (mg/wk)	P	R²	n	Warfarin dose (mg/wk)	P	R²
−1639G>A
GG	124	46 ± 17	<.001	0.28	105	47 ± 17	<.001	0.13
GA	156	33 ± 11			18	33 ± 15
AA	41	23 ± 7			2	23 ± 13
1173C>T
CC	123	45 ± 17	<.001	0.25	104	47 ± 17	<.001	0.14
CT	152	33 ± 11			18	32 ± 15
TT	42	25 ± 11			2	23 ± 13
1542G>C
GG	121	46 ± 18	<.001	0.22	63	45 ± 16	.59	0.002
GC	155	33 ± 11			50	45 ± 17
CC	45	24 ± 8			11	42 ± 23