Table 2.

Risk of myocardial infarction with increasing quintile of factor XIc and factor XIIc overall and in men younger than age 50




Patients

Control subjects

OR (95% CI)*

OR (95% CI)

OR (95% CI)
Factor XIc      
    Overall, N   560   646     
        55%-94%   69   133   1§  1§  1§ 
        95%-103%   117   136   1.7 (1.1-2.4)   1.9 (1.3-2.7)   2.0 (1.0-3.8)  
        104%-112%   117   121   1.8 (1.2-2.7)   2.2 (1.5-3.4)   2.7 (1.4-5.3)  
        113%-126%   132   128   2.0 (1.3-2.9)   2.9 (1.9-4.4)   2.7 (1.4-5.3)  
        127%-194%   125   128   1.8 (1.2-2.7)   3.2 (2.1-4.9)   2.5 (1.2-5.1)  
    Younger than 50 y, no.   154   160     
        55%-94%   9   34   1§  1§  1§ 
        95%-103%   31   31   3.4 (1.4-8.4)   4.2 (1.7-10.7)   12.7 (1.4-113.6)  
        104%-112%   39   31   4.1 (1.7-9.9)   5.5 (2.1-14.0)   19.5 (2.1-178.0)  
        113%-126%   30   29   3.3 (1.3-8.3)   4.4 (1.7-11.5)   14.8 (1.6-136.1)  
        127%-194%   45   35   4.4 (1.9-10.5)   6.6 (2.5-17.3)   19.0 (2.0-182.0)  
Factor XIIc      
    Overall, N   560   646     
        23%-79%   144   132   1§  1§  1§ 
        80%-95%   133   132   0.9 (0.6-1.3)   0.8 (0.5-1.1)   1.0 (0.6-1.8)  
        96%-106%   132   122   1.0 (0.7-1.4)   0.8 (0.5-1.1)   1.0 (0.6-1.7)  
        107%-118%   95   131   0.6 (0.4-0.9)   0.5 (0.3-0.7)   0.7 (0.4-1.3)  
        119%-164%   56   129   0.4 (0.2-0.5)   0.2 (0.1-0.4)   0.3 (0.1-0.6)  
    Younger than 50 y, no.   154   160     
        23%-79%   29   32   1§  1§  1§ 
        80%-95%   38   33   1.2 (0.6-2.4)   1.1 (0.5-2.3)   0.7 (0.2-2.0)  
        96%-106%   33   28   1.3 (0.6-2.8)   1.1 (0.5-2.3)   0.9 (0.3-2.7)  
        107%-118%   30   31   1.1 (0.5-2.2)   0.8 (0.4-1.7)   1.0 (0.4-2.7)  
        119%-164%
 
24
 
36
 
0.7 (0.4-1.5)
 
0.4 (0.2-1.0)
 
0.3 (0.1-1.0)
 



Patients

Control subjects

OR (95% CI)*

OR (95% CI)

OR (95% CI)
Factor XIc      
    Overall, N   560   646     
        55%-94%   69   133   1§  1§  1§ 
        95%-103%   117   136   1.7 (1.1-2.4)   1.9 (1.3-2.7)   2.0 (1.0-3.8)  
        104%-112%   117   121   1.8 (1.2-2.7)   2.2 (1.5-3.4)   2.7 (1.4-5.3)  
        113%-126%   132   128   2.0 (1.3-2.9)   2.9 (1.9-4.4)   2.7 (1.4-5.3)  
        127%-194%   125   128   1.8 (1.2-2.7)   3.2 (2.1-4.9)   2.5 (1.2-5.1)  
    Younger than 50 y, no.   154   160     
        55%-94%   9   34   1§  1§  1§ 
        95%-103%   31   31   3.4 (1.4-8.4)   4.2 (1.7-10.7)   12.7 (1.4-113.6)  
        104%-112%   39   31   4.1 (1.7-9.9)   5.5 (2.1-14.0)   19.5 (2.1-178.0)  
        113%-126%   30   29   3.3 (1.3-8.3)   4.4 (1.7-11.5)   14.8 (1.6-136.1)  
        127%-194%   45   35   4.4 (1.9-10.5)   6.6 (2.5-17.3)   19.0 (2.0-182.0)  
Factor XIIc      
    Overall, N   560   646     
        23%-79%   144   132   1§  1§  1§ 
        80%-95%   133   132   0.9 (0.6-1.3)   0.8 (0.5-1.1)   1.0 (0.6-1.8)  
        96%-106%   132   122   1.0 (0.7-1.4)   0.8 (0.5-1.1)   1.0 (0.6-1.7)  
        107%-118%   95   131   0.6 (0.4-0.9)   0.5 (0.3-0.7)   0.7 (0.4-1.3)  
        119%-164%   56   129   0.4 (0.2-0.5)   0.2 (0.1-0.4)   0.3 (0.1-0.6)  
    Younger than 50 y, no.   154   160     
        23%-79%   29   32   1§  1§  1§ 
        80%-95%   38   33   1.2 (0.6-2.4)   1.1 (0.5-2.3)   0.7 (0.2-2.0)  
        96%-106%   33   28   1.3 (0.6-2.8)   1.1 (0.5-2.3)   0.9 (0.3-2.7)  
        107%-118%   30   31   1.1 (0.5-2.2)   0.8 (0.4-1.7)   1.0 (0.4-2.7)  
        119%-164%
 
24
 
36
 
0.7 (0.4-1.5)
 
0.4 (0.2-1.0)
 
0.3 (0.1-1.0)
 
*

Adjusted for age.

Adjusted for age and either factor XIIc or factor XIc, each as continuous factor.

Adjusted for age, either factor XIIc or factor XIc each as a continuous factor; total cholesterol, HDL-cholesterol, and triglyceride levels; quetelet index; smoking; alcohol use; and diabetes, excluding persons having hypertension.

§

Reference group.

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