Table 2 Patient and disease... | American Society of Hematology

Table 2

Patient and disease characteristics

Patient no.	Sex	Age, y	Disease	Prior SCT	CNS relapse site	Isolated CNS relapse (systemic disease status)	Dasatinib as first-line therapy for CNS disease	Enrolled into dasatinib clinical trials
1	Male	66	Ph⁺ ALL	No	CSF	No	Yes	Yes
2	Male	41	Ly-BC-CML	Yes	CSF	Yes (stable MRD)	Yes	No*
3	Male	7	Ph⁺ ALL	Yes	CSF	Yes (stable MRD)	Yes	Yes
4	Male	13	Ph⁺ ALL	Yes (×2)	CSF	No	Yes	Yes
5	Female	59	BC-CML	Yes	Brain tumor (MRI)	Yes (CP)	Yes	No*
6	Male	41	My-BC-CML	No	Brain tumors (MRI)	No	Yes	Yes
7	Female	25	Ph⁺ ALL	No	CSF	Yes (stable MRD)	Yes	Yes
8	Female	35	Ph+ ALL	Yes	CSF + brain tumors (MRI)	Yes (stable MRD)	Yes	Yes
9	Male	59	My-BC-CML	Yes	CSF	Yes (stable MRD)	Yes	No*
10	Male	12	Ph⁺ ALL	Yes	CSF	No	Yes	Yes
11	Male	10	Ph⁺ ALL	Yes (×2)	CSF	No	Yes	Yes
12	Male	49	Ph⁺ ALL	Yes	CSF	Yes (stable MRD)	No	Yes
13	Male	79	My-BC-CML	No	CSF	Yes (stable MRD)	No	Yes
14	Male	26	Ly-BC-CML	No	CSF	Yes (CP)	No	No*

Patient no.	Sex	Age, y	Disease	Prior SCT	CNS relapse site	Isolated CNS relapse (systemic disease status)	Dasatinib as first-line therapy for CNS disease	Enrolled into dasatinib clinical trials
1	Male	66	Ph⁺ ALL	No	CSF	No	Yes	Yes
2	Male	41	Ly-BC-CML	Yes	CSF	Yes (stable MRD)	Yes	No*
3	Male	7	Ph⁺ ALL	Yes	CSF	Yes (stable MRD)	Yes	Yes
4	Male	13	Ph⁺ ALL	Yes (×2)	CSF	No	Yes	Yes
5	Female	59	BC-CML	Yes	Brain tumor (MRI)	Yes (CP)	Yes	No*
6	Male	41	My-BC-CML	No	Brain tumors (MRI)	No	Yes	Yes
7	Female	25	Ph⁺ ALL	No	CSF	Yes (stable MRD)	Yes	Yes
8	Female	35	Ph+ ALL	Yes	CSF + brain tumors (MRI)	Yes (stable MRD)	Yes	Yes
9	Male	59	My-BC-CML	Yes	CSF	Yes (stable MRD)	Yes	No*
10	Male	12	Ph⁺ ALL	Yes	CSF	No	Yes	Yes
11	Male	10	Ph⁺ ALL	Yes (×2)	CSF	No	Yes	Yes
12	Male	49	Ph⁺ ALL	Yes	CSF	Yes (stable MRD)	No	Yes
13	Male	79	My-BC-CML	No	CSF	Yes (stable MRD)	No	Yes
14	Male	26	Ly-BC-CML	No	CSF	Yes (CP)	No	No*

SCT indicates stem cell transplantation; CNS, central nervous system; Ph⁺ ALL, Philadelphia chromosome–positive acute lymphoblastic leukemia; Ly-BC-CML, lymphoid blast crisis of CML; My-BC-CML, myeloid blast crisis of chronic myeloid leukemia; CSF, cerebrospinal fluid; MRI, magnetic resonance imaging; MRD, minimal residual disease; and CP, chronic phase.

Enrolled in compassionate use programs.

View Large

This Feature Is Available To Subscribers Only