Impact of lkL/L mutation on peripheral dendritic cell subsets
. | Spleen . | . | Lymph node† . | . | ||
|---|---|---|---|---|---|---|
| Subset*genotype . | %‡ . | No. of cells, × 10-4 . | %‡ . | No. of cells, × 10-3 . | ||
| pDC | ||||||
| WT | 0.29 (0.04) | 25.7 (0.48) | 0.08 (0.009) | 3.41 (0.40) | ||
| IkL/+ | 0.08 (0.01) | 6.7 (1.0) | 0.04 (0.006) | 2.05 (0.27) | ||
| IkL/L | 0.002 (0.003) | 0.11 (0.19) | 0.001 (0.002) | 0.041 (0.081) | ||
| CD8α+ | ||||||
| WT | 0.43 (0.21) | 37.9 (1.8) | 0.07 (0.01) | 2.78 (0.45) | ||
| IkL/+ | 0.34 (0.02) | 28.2 (0.15) | 0.07 (0.005) | 3.08 (0.37) | ||
| IkL/L | 0.60 (0.17) | 41.7 (9.9) | 0.08 (0.01) | 3.09 (0.43) | ||
| CD11b+ | ||||||
| WT | 0.54 (0.20) | 52.0 (13.1) | 0.09 (0.01) | 3.68 (0.36) | ||
| IkL/+ | 0.46 (0.04) | 37.8 (3.4) | 0.09 (0.01) | 3.98 (0.16) | ||
| IkL/L | 0.66 (0.10) | 45.8 (3.4) | 0.10 (0.01) | 3.36 (0.31) | ||
. | Spleen . | . | Lymph node† . | . | ||
|---|---|---|---|---|---|---|
| Subset*genotype . | %‡ . | No. of cells, × 10-4 . | %‡ . | No. of cells, × 10-3 . | ||
| pDC | ||||||
| WT | 0.29 (0.04) | 25.7 (0.48) | 0.08 (0.009) | 3.41 (0.40) | ||
| IkL/+ | 0.08 (0.01) | 6.7 (1.0) | 0.04 (0.006) | 2.05 (0.27) | ||
| IkL/L | 0.002 (0.003) | 0.11 (0.19) | 0.001 (0.002) | 0.041 (0.081) | ||
| CD8α+ | ||||||
| WT | 0.43 (0.21) | 37.9 (1.8) | 0.07 (0.01) | 2.78 (0.45) | ||
| IkL/+ | 0.34 (0.02) | 28.2 (0.15) | 0.07 (0.005) | 3.08 (0.37) | ||
| IkL/L | 0.60 (0.17) | 41.7 (9.9) | 0.08 (0.01) | 3.09 (0.43) | ||
| CD11b+ | ||||||
| WT | 0.54 (0.20) | 52.0 (13.1) | 0.09 (0.01) | 3.68 (0.36) | ||
| IkL/+ | 0.46 (0.04) | 37.8 (3.4) | 0.09 (0.01) | 3.98 (0.16) | ||
| IkL/L | 0.66 (0.10) | 45.8 (3.4) | 0.10 (0.01) | 3.36 (0.31) | ||
Mean absolute cell numbers derived from 3 mice were calculated by multiplying the total cell numbers by the percent cells within each population. Standard deviations are indicated in parentheses.
DC subsets were defined as illustrated in Figure 1.
Data are derived from a single axillary lymph node from each mouse following liberase treatment.
Mean percent of gated population of three 7-week-old mice per group. Standard deviations are indicated with parentheses.