Table 1. Action of fludarabine on... | American Society of Hematology

Table 1.

Action of fludarabine on formation of oxaliplatin ICL in specific genes of CLL lymphocytes

		ICL/10 kb*
Oxaliplatin, μM	Gene size, kb	-F-ara-A	+F-ara-A
*DHFR*	22
100		0.14	0.26
200		0.31	0.63
400		0.60	1.16†
δ-Globin	18
100		0.08	0.19
200		0.19	0.42
400		0.43	0.87†
mtDNA	16.5
100		0.12	0.22
200		0.27	0.56
400		0.51	1.05†

		ICL/10 kb*
Oxaliplatin, μM	Gene size, kb	-F-ara-A	+F-ara-A
*DHFR*	22
100		0.14	0.26
200		0.31	0.63
400		0.60	1.16†
δ-Globin	18
100		0.08	0.19
200		0.19	0.42
400		0.43	0.87†
mtDNA	16.5
100		0.12	0.22
200		0.27	0.56
400		0.51	1.05†

Values represent ICL/10 kb. Data are from at least 3 blots each of 3 independent biologic experiments. Standard errors were in the range of 0 to 0.09 ICL per fragment.

†

P < .05 (significance evaluated at 400 mM oxaliplatin).

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