As2O3 effects on MRL+/+ and MRL/lpr mouse tissue/organ weights
. | MRL+/+ . | . | MRL/lpr . | . | ||
|---|---|---|---|---|---|---|
| Tissue/organ . | PBS . | As2O3 . | PBS . | As2O3 . | ||
| Axillary LN | 10 ± 1 | 10 ± 1 | 450 ± 10 | 20 ± 1 | ||
| Mesenteric LN | 50 ± 3 | 45 ± 3 | 2410 ± 100 | 70 ± 7 | ||
| Spleen | 100 ± 3 | 120 ± 10 | 630 ± 40 | 170 ± 3 | ||
| Liver | 2460 ± 50 | 2620 ± 80 | 3760 ± 90 | 2750 ± 35 | ||
| Lung | 320 ± 30 | 330 ± 20 | 550 ± 20 | 400 ± 7 | ||
| Kidney | 400 ± 3 | 420 ± 10 | 510 ± 10 | 540 ± 2 | ||
| Heart | 220 ± 10 | 210 ± 3 | 290 ± 7 | 240 ± 3 | ||
| No. mice in group | 5 | 5 | 6 | 10 | ||
. | MRL+/+ . | . | MRL/lpr . | . | ||
|---|---|---|---|---|---|---|
| Tissue/organ . | PBS . | As2O3 . | PBS . | As2O3 . | ||
| Axillary LN | 10 ± 1 | 10 ± 1 | 450 ± 10 | 20 ± 1 | ||
| Mesenteric LN | 50 ± 3 | 45 ± 3 | 2410 ± 100 | 70 ± 7 | ||
| Spleen | 100 ± 3 | 120 ± 10 | 630 ± 40 | 170 ± 3 | ||
| Liver | 2460 ± 50 | 2620 ± 80 | 3760 ± 90 | 2750 ± 35 | ||
| Lung | 320 ± 30 | 330 ± 20 | 550 ± 20 | 400 ± 7 | ||
| Kidney | 400 ± 3 | 420 ± 10 | 510 ± 10 | 540 ± 2 | ||
| Heart | 220 ± 10 | 210 ± 3 | 290 ± 7 | 240 ± 3 | ||
| No. mice in group | 5 | 5 | 6 | 10 | ||
Two-month-old MRL+/+ and MRL/lpr mice had been treated daily with PBS or As2O3 (5 μg/g) for 2 months. Results, save for those in the last row, are expressed as mean organ weights in milligrams ± SE.