Table 1.

Clinical characteristics and p-AKT Ser473 expression status of patients with DLBCL

High p-AKT
Low p-AKT
Total
n
%
n
%
P
No. of patients   64   35   55   29   45   
Age, y       .279  
    60 or younger   35   17   49   18   51   
    Older than 60   29   18   62   11   38   
Sex       .330  
    Female   17   11   65   6   35   
    Male   47   24   51   23   49   
Performance status       .133  
    Lower than 2   40   19   48   21   52   
    2 or higher   24   16   67   8   33   
Stage       .225  
    I or II   30   14   47   16   53   
    III or IV   34   21   62   13   38   
Extranodal sites involved       .01  
    1 site   40   17   43   23   57   
    More than 1 site   24   18   75   6   25   
LDH level*       .343  
    Normal   26   12   46   14   54   
    High   36   21   58   15   42   
IPI       .111  
    Low to low-intermediate   35   16   46   19   54   
    High-intermediate to high   29   19   66   10   34   
B symptoms       .003  
    Absent   29   10   35   19   65   
    Present   35   25   71   10   29   
Ki-67 expression (n = 95)       .009  
    Positive   83   46   55   37   45   
    Negative
 		 12
 		 2
 		 17
 		 10
 		 83
 
 
High p-AKT
Low p-AKT
Total
n
%
n
%
P
No. of patients   64   35   55   29   45   
Age, y       .279  
    60 or younger   35   17   49   18   51   
    Older than 60   29   18   62   11   38   
Sex       .330  
    Female   17   11   65   6   35   
    Male   47   24   51   23   49   
Performance status       .133  
    Lower than 2   40   19   48   21   52   
    2 or higher   24   16   67   8   33   
Stage       .225  
    I or II   30   14   47   16   53   
    III or IV   34   21   62   13   38   
Extranodal sites involved       .01  
    1 site   40   17   43   23   57   
    More than 1 site   24   18   75   6   25   
LDH level*       .343  
    Normal   26   12   46   14   54   
    High   36   21   58   15   42   
IPI       .111  
    Low to low-intermediate   35   16   46   19   54   
    High-intermediate to high   29   19   66   10   34   
B symptoms       .003  
    Absent   29   10   35   19   65   
    Present   35   25   71   10   29   
Ki-67 expression (n = 95)       .009  
    Positive   83   46   55   37   45   
    Negative
 		 12
 		 2
 		 17
 		 10
 		 83
 
 
*

LDH categorization is based on the range for normal values in the clinical laboratory at our institution. LDH levels were missing in 2 patients but both patients had a total IPI score of 4 and were categorized in the high-risk group.

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