Summary of the Levels of Surface Expression of Molecules Studied on JAK3-Deficient B Cells in Response to CD40 Ligation
| % CD19+ Cells Expressing . | Patients . | Controls . | ||
|---|---|---|---|---|
| — . | CD40L:CD8 . | — . | CD40L:CD8 . | |
| CD23+ | 22 | 55 (n = 4) | 19 | 75 (n = 3) |
| ICAM-1+ | 19 | 80 (n = 4) | 15 | 87 (n = 3) |
| CD80+ | 29 | 55 (n = 2) | 20 | 54 (n = 3) |
| LT-α+ | 9 | 38 (n = 2) | 20 | 55 (n = 2) |
| % CD19+ Cells Expressing . | Patients . | Controls . | ||
|---|---|---|---|---|
| — . | CD40L:CD8 . | — . | CD40L:CD8 . | |
| CD23+ | 22 | 55 (n = 4) | 19 | 75 (n = 3) |
| ICAM-1+ | 19 | 80 (n = 4) | 15 | 87 (n = 3) |
| CD80+ | 29 | 55 (n = 2) | 20 | 54 (n = 3) |
| LT-α+ | 9 | 38 (n = 2) | 20 | 55 (n = 2) |
PBMCs from patients or normal controls were cultured for 24 hours with or without soluble mouse-CD40L:CD8 fusion protein + rat anti-mouse CD8. Cells were washed and stained as described in Materials and Methods. Results shown are the mean values of CD19+ cells expressing the different cell surface markers studied in response to CD40 ligation. n = number of donors studied.