Failure of Anti–MIP-1α Antibodies to Block the Return to a Quiescent State Within 4 to 5 Days of Previously Activated Primitive Normal Progenitors in LTC Adherent Layers
| Addition . | % Kill After3H-Thymidine . | |
|---|---|---|
| Primitive BFU-E . | Primitive CFU-GM . | |
| None | 6 ± 3 | 0 ± 5 |
| MIP-1β | 41 ± 8 | 31 ± 3 |
| Anti–MIP-1α | 2 ± 5 | 8 ± 8 |
| Control Ig | 7 ± 4 | 0 ± 8 |
| Addition . | % Kill After3H-Thymidine . | |
|---|---|---|
| Primitive BFU-E . | Primitive CFU-GM . | |
| None | 6 ± 3 | 0 ± 5 |
| MIP-1β | 41 ± 8 | 31 ± 3 |
| Anti–MIP-1α | 2 ± 5 | 8 ± 8 |
| Control Ig | 7 ± 4 | 0 ± 8 |
MIP-1β at 300 ng/mL, anti–MIP-1α and control Ig at 100 to 200 μg/mL. Results shown are the mean ±SEM of data obtained in seven independent experiments. The effect of MIP-1β addition is highly significant (P < .005) by comparison with no addition, whereas the effect of anti–MIP-1α or control Ig is not (P > .3).