The CML-like illness is readily transplantable to secondary recipients, irrespective of the hematopoietic response of the bone marrow donor to STI571 at the time of transplantation
| Secondary recipient . | Treatment . | Outcome . | Spleen weight, mg . | WBC, per μL . |
|---|---|---|---|---|
| Secondary BMT donor: STI571 no. 4, | ||||
| STI571-responsive*,† | ||||
| No. 1 | None | Died d23 CML | ND | ND |
| No. 2 | None | Died d23 CML | 700 | 760 000 |
| No. 3 | None | Died d23 CML | 746 | 624 000 |
| No. 4 | STI571 begun d23 | Died d28 CML, HLP | ND | ND |
| (WBC = 176 000/μL) | ||||
| Secondary BMT donor: STI571 no. 6, STI571 nonresponsive*,‡ | ||||
| No. 1 | None | Died d22 CML | 1140 | ND |
| No. 2 | STI571 begun d22 | Died d31 CML, HLP | 577 | 112 000 |
| (WBC = 33 000/μL) | ||||
| No. 3 | None | Died d27 CML | ND | ND |
| No. 4 | None | NED d117 | ND | 6 000 (d29) |
| Secondary recipient . | Treatment . | Outcome . | Spleen weight, mg . | WBC, per μL . |
|---|---|---|---|---|
| Secondary BMT donor: STI571 no. 4, | ||||
| STI571-responsive*,† | ||||
| No. 1 | None | Died d23 CML | ND | ND |
| No. 2 | None | Died d23 CML | 700 | 760 000 |
| No. 3 | None | Died d23 CML | 746 | 624 000 |
| No. 4 | STI571 begun d23 | Died d28 CML, HLP | ND | ND |
| (WBC = 176 000/μL) | ||||
| Secondary BMT donor: STI571 no. 6, STI571 nonresponsive*,‡ | ||||
| No. 1 | None | Died d22 CML | 1140 | ND |
| No. 2 | STI571 begun d22 | Died d31 CML, HLP | 577 | 112 000 |
| (WBC = 33 000/μL) | ||||
| No. 3 | None | Died d27 CML | ND | ND |
| No. 4 | None | NED d117 | ND | 6 000 (d29) |
BMT indicates bone marrow transplant; ND, not done; HLP, hind-limb paralysis; NED, no clinical evidence of disease.
CML animals treated with STI571 were used as BMT donors for sublethally irradiated syngeneic recipients.
For this donor, WBC = 10 000/μL at time of BM harvest, which was 101 days after BM reconstitution and after 91 days of STI571 treatment.
For this donor, WBC = 329 000/μL at time of BM harvest, which was 34 days after BM reconstitution and after 24 days of STI571 treatment.