High-Dose Regimens Used in 55 Patients With APB
| High-Dose Regimen . | Transplant × 2 . | Transplant × 1 . |
|---|---|---|
| Mel 200 | 33 | 9 |
| Mel 140/TBI | 0 | 1 |
| Mel 200 then Mel/TBI | 5 | — |
| Mel 200 then Mel/Cy | 6 | — |
| Mel 140 then Cy/carbo/etoposide | 1 | — |
| High-Dose Regimen . | Transplant × 2 . | Transplant × 1 . |
|---|---|---|
| Mel 200 | 33 | 9 |
| Mel 140/TBI | 0 | 1 |
| Mel 200 then Mel/TBI | 5 | — |
| Mel 200 then Mel/Cy | 6 | — |
| Mel 140 then Cy/carbo/etoposide | 1 | — |
Melphalan was used alone in a dose of 200 mg/m2 (Mel 200) or at a dose of 140 mg/m2 together with total body irradiation (Mel 140/TBI) (radiation dose of 850 to 1,125 cGy) or with cyclophosphamide (dose 100 to 120 mg/kg) (Mel/Cy). One patient had a first transplant after Mel 140 and a second high-dose therapy with cyclophosphamide, carboplatin (carbo), and etoposide.