Table 1. Clinical and Immunological... | American Society of Hematology

Table 1.

Clinical and Immunological Status of Lymphoma-Bearing Monkeys (4, 8503, OD5, 208, S1) Compared With That of Monkeys Which Did Not Develop Lymphomas (C1, 8302, H8, OD3, 203)

Monkey Code	Treatment	SIV Strain^*	Ab Anti-SIV^-151	VC^-152	PCR^-153	Time to Death After Infection (wk)	SIV Disease	Immune Status^-155 (before death)				Lymphoma
Monkey Code	Treatment	SIV Strain^*	Ab Anti-SIV^-151	VC^-152	PCR^-153	Time to Death After Infection (wk)	SIV Disease	CD20⁺	CD2⁺	CD4⁺	CD8⁺	Lymphoma
4	Vaccinated¶	SIVmac251	4.4	+	+	81	Chronic	340	1,500	210	1,710	+
8503	Vaccinated	SIVmac251/32H	4.4	+	+	139	Chronic	500	780	80	790	+
OD5#	Naive infected	SIVmac251	4.7	+	+	124	Chronic	670	9,450	200	10,040	+
208	Naive infected	SIVmac251/32H	5.0	+	+	94	Chronic	380	1,590	50	440	+
S1	Naive infected	SIVmac251/32H	<2.0	+	+	12	Acute	248	1,292	795	745	+
C1	Vaccinated	SIVmac251/32H	5.0	+	+	106	Chronic	380	1,140	80	1,220	−
8302	Vaccinated	SIVmac251/32H	5.0	+	+	125	Chronic	190	650	200	480	−
OD3	Naive infected	SIVmac251	5.3	+	+	71	Chronic	540	1,560	390	1,510	−
203	Naive infected	SIVmac251/32H	5.0	+	+	66	Chronic	680	1,020	20	1,330	−
H8	Naive infected	SIVmac251/32H	<2.0	+	+	16	Acute	849	3,184	1,592	1,432	−

Monkey Code	Treatment	SIV Strain^*	Ab Anti-SIV^-151	VC^-152	PCR^-153	Time to Death After Infection (wk)	SIV Disease	Immune Status^-155 (before death)				Lymphoma
Monkey Code	Treatment	SIV Strain^*	Ab Anti-SIV^-151	VC^-152	PCR^-153	Time to Death After Infection (wk)	SIV Disease	CD20⁺	CD2⁺	CD4⁺	CD8⁺	Lymphoma
4	Vaccinated¶	SIVmac251	4.4	+	+	81	Chronic	340	1,500	210	1,710	+
8503	Vaccinated	SIVmac251/32H	4.4	+	+	139	Chronic	500	780	80	790	+
OD5#	Naive infected	SIVmac251	4.7	+	+	124	Chronic	670	9,450	200	10,040	+
208	Naive infected	SIVmac251/32H	5.0	+	+	94	Chronic	380	1,590	50	440	+
S1	Naive infected	SIVmac251/32H	<2.0	+	+	12	Acute	248	1,292	795	745	+
C1	Vaccinated	SIVmac251/32H	5.0	+	+	106	Chronic	380	1,140	80	1,220	−
8302	Vaccinated	SIVmac251/32H	5.0	+	+	125	Chronic	190	650	200	480	−
OD3	Naive infected	SIVmac251	5.3	+	+	71	Chronic	540	1,560	390	1,510	−
203	Naive infected	SIVmac251/32H	5.0	+	+	66	Chronic	680	1,020	20	1,330	−
H8	Naive infected	SIVmac251/32H	<2.0	+	+	16	Acute	849	3,184	1,592	1,432	−

*SIV strain used to infect the monkeys. SIVmac251/32H derived from an in vivo passage of SIVmac251.

F0-151

End-point anti-SIV antibody titers detected by ELISA.

F0-152

Viral isolation by coculture with C8166 human T-cell line.

F0-153

PCR DNA analysis using primers amplifying the gag region of SIV.

F0-155

Number of CD20⁺, CD2⁺, CD4⁺, and CD8⁺ cells (×10³/mL) as determined from the last bleeding before death.

¶Formalin-inactivated whole SIV derived from HUT-78 chronically infected cells.

#Monkey OD5 was splenectomized 1 year after infection.

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