Results of ANOVA
| Effect . | Bone Marrow . | Spleen . | Total Body (bm + s) . | Blood . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BFU-E . | CFU-E . | CFU-GM . | BFU-E . | CFU-E . | CFU-GM . | BFU-E . | CFU-E . | CFU-GM . | RET . | HKT . | GRA . | PLT . | |
| Log-transformation | x | x | x | x | x | x | x | x | x | x | |||
| EPO | <.0001 | <.0001 | <.0001 | <.0001 | <.0059 | <.0001 | <.0001 | <.0001 | <.0001 | .0008 | |||
| ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ||||
| G-CSF | <.0001 | <.0001 | <.0001 | <.0001 | <.0001 | <.0001 | <.0001 | .0022 | <.0001 | <.0001 | |||
| ↓ | ↓ | ↓ | ↑ | ↑ | ↑ | ↓ | ↓ | ↑ | ↓ | ||||
| IL-11 | .0005 | <.0001 | <.0001 | <.0001 | <.0001 | <.0001 | <.0001 | <.0001 | <.0001 | <.0001 | .0032 | ||
| ↓ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ↓ | ↑ | ↑ | |||
| SCF | <.0001 | <.0001 | <.0001 | <.0001 | <.0001 | <.0001 | <.0001 | .0047 | |||||
| ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ↓ | ||||||
| EPO × G-CSF | .0064 | .0026 | .0057 | ||||||||||
| 1C | 1B | 1F | 1A | 1H | |||||||||
| EPO × IL-11 | |||||||||||||
| 1G | 1D | 1E | |||||||||||
| EPO × SCF | |||||||||||||
| G-CSF × IL-11 | .0067 | .0010 | .0046 | ||||||||||
| 2G | 2F | 2E | |||||||||||
| G-CSF × SCF | <.0001 | .0062 | .0005 | .0061 | <.0001 | <.0001 | .0004 | ||||||
| 2B | 2D | 2J | 2A | 2C | 2I | 2H | 2K | ||||||
| SCF × IL-11 | <.0001 | <.0001 | |||||||||||
| 3B | 3D | 3A | 3C | 3E | |||||||||
| EPO × G-CSF × IL-11 | |||||||||||||
| EPO × G-CSF × SCF | |||||||||||||
| EPO × SCF × IL-11 | |||||||||||||
| G-CSF × SCF × IL-11 | .0001 | .0001 | |||||||||||
| EPO × G-CSF × SCF × IL-11 | Missing | Missing | |||||||||||
| Effect . | Bone Marrow . | Spleen . | Total Body (bm + s) . | Blood . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BFU-E . | CFU-E . | CFU-GM . | BFU-E . | CFU-E . | CFU-GM . | BFU-E . | CFU-E . | CFU-GM . | RET . | HKT . | GRA . | PLT . | |
| Log-transformation | x | x | x | x | x | x | x | x | x | x | |||
| EPO | <.0001 | <.0001 | <.0001 | <.0001 | <.0059 | <.0001 | <.0001 | <.0001 | <.0001 | .0008 | |||
| ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ||||
| G-CSF | <.0001 | <.0001 | <.0001 | <.0001 | <.0001 | <.0001 | <.0001 | .0022 | <.0001 | <.0001 | |||
| ↓ | ↓ | ↓ | ↑ | ↑ | ↑ | ↓ | ↓ | ↑ | ↓ | ||||
| IL-11 | .0005 | <.0001 | <.0001 | <.0001 | <.0001 | <.0001 | <.0001 | <.0001 | <.0001 | <.0001 | .0032 | ||
| ↓ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ↓ | ↑ | ↑ | |||
| SCF | <.0001 | <.0001 | <.0001 | <.0001 | <.0001 | <.0001 | <.0001 | .0047 | |||||
| ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ↓ | ||||||
| EPO × G-CSF | .0064 | .0026 | .0057 | ||||||||||
| 1C | 1B | 1F | 1A | 1H | |||||||||
| EPO × IL-11 | |||||||||||||
| 1G | 1D | 1E | |||||||||||
| EPO × SCF | |||||||||||||
| G-CSF × IL-11 | .0067 | .0010 | .0046 | ||||||||||
| 2G | 2F | 2E | |||||||||||
| G-CSF × SCF | <.0001 | .0062 | .0005 | .0061 | <.0001 | <.0001 | .0004 | ||||||
| 2B | 2D | 2J | 2A | 2C | 2I | 2H | 2K | ||||||
| SCF × IL-11 | <.0001 | <.0001 | |||||||||||
| 3B | 3D | 3A | 3C | 3E | |||||||||
| EPO × G-CSF × IL-11 | |||||||||||||
| EPO × G-CSF × SCF | |||||||||||||
| EPO × SCF × IL-11 | |||||||||||||
| G-CSF × SCF × IL-11 | .0001 | .0001 | |||||||||||
| EPO × G-CSF × SCF × IL-11 | Missing | Missing | |||||||||||
P values are given for all effects with P < .01; main effect direction is given by arrows; numbers of corresponding figures are given for interaction effects.
Abbreviations: RET, reticulocytes; HKT, hematocrit; GRA, granulocytes; PLT, platelets.