Expression Values (AU; mean ± SD) for Granzyme A, CD3, and IL-10 mRNA in Skin Samples
| . | CD3 . | Granzyme A . | IL-10 . |
|---|---|---|---|
| Mycosis fungoides | |||
| Patch stage (n = 11) | 387 ± 186* | 132 ± 131 | 76 ± 73 |
| Plaque stage (n = 5) | 407 ± 217* | 196 ± 135 | 140 ± 95 |
| Tumor stage (n = 3) | 620 ± 417 | 360 ± 200 | 283 ± 115 |
| Pleomorphic TCL (n = 5) | 1,337 ± 599* | 457 ± 181 | 574 ± 591 |
| Psoriasis (n = 7) | 145 ± 164 | 49 ± 62 | 45 ± 16 |
| Atopic dermatitis (n = 5) | 147 ± 61 | 44 ± 51 | 346 ± 302* |
| Normal skin (n = 8) | 64 ± 55 | 59 ± 60 | 44 ± 25 |
| . | CD3 . | Granzyme A . | IL-10 . |
|---|---|---|---|
| Mycosis fungoides | |||
| Patch stage (n = 11) | 387 ± 186* | 132 ± 131 | 76 ± 73 |
| Plaque stage (n = 5) | 407 ± 217* | 196 ± 135 | 140 ± 95 |
| Tumor stage (n = 3) | 620 ± 417 | 360 ± 200 | 283 ± 115 |
| Pleomorphic TCL (n = 5) | 1,337 ± 599* | 457 ± 181 | 574 ± 591 |
| Psoriasis (n = 7) | 145 ± 164 | 49 ± 62 | 45 ± 16 |
| Atopic dermatitis (n = 5) | 147 ± 61 | 44 ± 51 | 346 ± 302* |
| Normal skin (n = 8) | 64 ± 55 | 59 ± 60 | 44 ± 25 |
Abbreviation: TCL, T-cell lymphoma.
P < .01 (Mann-Whitney test) compared with normal skin. Granzyme A and IL-10 mRNA expression of the advanced stages of MF (plaque and tumor) but not of the early (patch) stage was significantly higher than in healthy and psoriatic skin (P < .01 Mann-Whitney test).