Summary of the 17 Minor H Antigens Defined by the CD8+ CTL Clones Described in This Report
| Minor H Antigen . | Representative Clone . | Donor/ Recipient Pair . | Restricting Element . | Population Frequency . | Hematopoietic Cells . | Fibroblasts . |
|---|---|---|---|---|---|---|
| A2-1 | PAM-13 | 1 | A2 | 0.70 | + | + |
| A2-2 | ATT-1 | 7 | A2 | 0.47 | + | + |
| A2-3 | ATT-3 | 7 | A2 | 0.28 | + | − |
| A2-4 | ATT-5 | 7 | A2 | 0.17 | + | − |
| A3-1 | DRN-7 | 5 | A3 | 0.74 | + | − |
| A11-1 | SJN-7 | 2 | A11 | (3/7) | + | + |
| A11-2 | SJN-9 | 2 | A11 | (6/7) | + | + |
| B7-1 | ATT-2 | 7 | B7 | 0.31 | + | − |
| B7-2 | ATT-4 | 7 | B7 | 0.92 | + | − |
| B7-3 | ATT-7 | 7 | B7 | 0.85 | + | − |
| B7-4 | ATT-8 | 7 | B7 | 0.77 | + | − |
| B7-5 | ATT-9 | 7 | B7 | 0.60 | + | + |
| B7-6 | DRN-11 | 5 | B7 | 0.56 | + | − |
| B8-1 | MRR-23 | 4 | B8 | 0.50 | + | − |
| B53-1 | DJG-7 | 8 | B53 | (1/4) | + | − |
| B53-2 | DJG-24 | 8 | B53 | (2/4) | + | − |
| Cw7-1 | DRN-14 | 5 | Cw7 | 0.70 | + | − |
| Minor H Antigen . | Representative Clone . | Donor/ Recipient Pair . | Restricting Element . | Population Frequency . | Hematopoietic Cells . | Fibroblasts . |
|---|---|---|---|---|---|---|
| A2-1 | PAM-13 | 1 | A2 | 0.70 | + | + |
| A2-2 | ATT-1 | 7 | A2 | 0.47 | + | + |
| A2-3 | ATT-3 | 7 | A2 | 0.28 | + | − |
| A2-4 | ATT-5 | 7 | A2 | 0.17 | + | − |
| A3-1 | DRN-7 | 5 | A3 | 0.74 | + | − |
| A11-1 | SJN-7 | 2 | A11 | (3/7) | + | + |
| A11-2 | SJN-9 | 2 | A11 | (6/7) | + | + |
| B7-1 | ATT-2 | 7 | B7 | 0.31 | + | − |
| B7-2 | ATT-4 | 7 | B7 | 0.92 | + | − |
| B7-3 | ATT-7 | 7 | B7 | 0.85 | + | − |
| B7-4 | ATT-8 | 7 | B7 | 0.77 | + | − |
| B7-5 | ATT-9 | 7 | B7 | 0.60 | + | + |
| B7-6 | DRN-11 | 5 | B7 | 0.56 | + | − |
| B8-1 | MRR-23 | 4 | B8 | 0.50 | + | − |
| B53-1 | DJG-7 | 8 | B53 | (1/4) | + | − |
| B53-2 | DJG-24 | 8 | B53 | (2/4) | + | − |
| Cw7-1 | DRN-14 | 5 | Cw7 | 0.70 | + | − |
Listed for each minor H antigen are a representative clone defining that minor H antigen, the class I MHC element that restricts recognition of the minor H antigen, the donor/recipient pair from whom this clone was isolated, the estimated phenotype frequency of the minor H antigen in the population bearing the restricting allele, and expression of the minor H antigen in hematopoietic cells and dermal fibroblasts (derived from single donors), as inferred from in vitro cytotoxicity assays. For those clones for which fewer than 10 unrelated EBV-LCL targets bearing the appropriate MHC restricting allele were available, the number of targets recognized/total number of targets tested is listed in parentheses in the place of the population frequency. (+) Greater than 30% lysis at E:T 20:1. (−) Less than 5% lysis at E:T 20:1. All clones were tested against 2 or more types of hematopoietic targets, including EBV-LCL, PHA blasts, and leukemic cells; a (+) appears if greater than 30% specific lysis at E:T 20:1 was demonstrable against any one of these hematopoietic targets.