Table 6.

Differentiation of Patients With MM From Patients With MGUS or Osteoporosis

ParameterMMMGUS (n = 40)Osteoporosis (n = 40)
Stage I and II (n = 23)Stage III (n = 27)All Stages (n = 50)
h-PYD 
≤50 μmol/mol 59% 12% 33% 87%6-151 85%6-151 
>50 μmol/mol 41%6-150 88%6-150 67%6-150 13% 15% 
h-DPD 
≤15 μmol/mol 64% 22% 40% 97%6-151 85%6-151 
>15 μmol/mol 46%6-150 78%6-150 60%6-150 3% 15% 
i-DPD 
≤8 μmol/mol 52% 7% 28% 95%6-151 62%6-151 
>8 μmol/mol 48%6-150 93%6-150 72%6-150 5% 38% 
ParameterMMMGUS (n = 40)Osteoporosis (n = 40)
Stage I and II (n = 23)Stage III (n = 27)All Stages (n = 50)
h-PYD 
≤50 μmol/mol 59% 12% 33% 87%6-151 85%6-151 
>50 μmol/mol 41%6-150 88%6-150 67%6-150 13% 15% 
h-DPD 
≤15 μmol/mol 64% 22% 40% 97%6-151 85%6-151 
>15 μmol/mol 46%6-150 78%6-150 60%6-150 3% 15% 
i-DPD 
≤8 μmol/mol 52% 7% 28% 95%6-151 62%6-151 
>8 μmol/mol 48%6-150 93%6-150 72%6-150 5% 38% 

Cutoff levels for the individual markers refer to the upper limit of their 95% confidence interval determined in the collective of healthy controls.

F6-150

Sensitivity.

F6-151

Specificity.

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