Table 3. Effect of the Extent of Bone... | American Society of Hematology

Table 3.

Effect of the Extent of Bone Disease on Biochemical Markers of Bone Resorption

Parameter	MGUS (n = 40)	Normocalcemic Myeloma			Hypercalcemic Myeloma
		Without Evidence of Bone Disease (n = 8)	Osteoporosis-Like Bone Involvement	Overt Lytic Bone Lesions (± osteoporosis)	(n = 8)^3-150
			(n = 10)	(n = 24)
Serum calcium (mmol/L)
Median	2.34	2.40	2.31	2.27	2.99‡ρ
Range	1.93-2.60	2.12-2.45	2.04-2.49	1.99-2.61	2.71-3.52
h-PYD (μmol/mol)
Median	28.2	47.9^3-151	50.6^‡	64.4^‡	69.7^‡
Range	11.7-63.6	23.4-73.0	36.1-751.9	25.8-773.7	48.3-127.8
h-DPD (μmol/mol)
Median	6.45	13.4^3-151	11.2^‡	21.0^‡	21.8^‡
Range	3.4-21.8	6.5-24.7	6.3-194.8	5.1-313.9	12.8-36.4
i-DPD (μmol/mol)
Median	5.1	6.9^3-151	10.7^‡	11.4^‡	9.9^‡
Range	0.56-8.66	4.4-17.7	6.7-122.5	4.6-170.7	8.6-14.7
uCa (mol/mol)
Median	0.35	0.32	0.44	0.43	1.1‡ρ
Range	0.04-3.11	0.01-0.95	0.05-18.44	0.08-23.38	0.23-2.51

Parameter	MGUS (n = 40)	Normocalcemic Myeloma			Hypercalcemic Myeloma
		Without Evidence of Bone Disease (n = 8)	Osteoporosis-Like Bone Involvement	Overt Lytic Bone Lesions (± osteoporosis)	(n = 8)^3-150
			(n = 10)	(n = 24)
Serum calcium (mmol/L)
Median	2.34	2.40	2.31	2.27	2.99‡ρ
Range	1.93-2.60	2.12-2.45	2.04-2.49	1.99-2.61	2.71-3.52
h-PYD (μmol/mol)
Median	28.2	47.9^3-151	50.6^‡	64.4^‡	69.7^‡
Range	11.7-63.6	23.4-73.0	36.1-751.9	25.8-773.7	48.3-127.8
h-DPD (μmol/mol)
Median	6.45	13.4^3-151	11.2^‡	21.0^‡	21.8^‡
Range	3.4-21.8	6.5-24.7	6.3-194.8	5.1-313.9	12.8-36.4
i-DPD (μmol/mol)
Median	5.1	6.9^3-151	10.7^‡	11.4^‡	9.9^‡
Range	0.56-8.66	4.4-17.7	6.7-122.5	4.6-170.7	8.6-14.7
uCa (mol/mol)
Median	0.35	0.32	0.44	0.43	1.1‡ρ
Range	0.04-3.11	0.01-0.95	0.05-18.44	0.08-23.38	0.23-2.51

Seven patients had lytic bone lesions and 1 patient had osteoporosis-like bone disease.

P < .025, ‡ P < .0001: v MGUS.

ρ P < .05 v 3 subgroups of normocalcemic myeloma patients.