HLA Class I Allele Frequencies in MC Patients Compared With Control Groups
Alleles . | Patients (%) n = 25 . | Pathological Controls (%) n = 30 . | Normal Controls (%) n = 377 . | RR . | pcI . | pcII . | pcIII . |
---|---|---|---|---|---|---|---|
A1 | 24.0 (6) | 16.7 (5) | 22.5 (85) | 1.1 | NS | NS | NS |
A2 | 60.0 (15) | 56.7 (17) | 46.1 (174) | 1.7 | NS | NS | NS |
A3 | 12.0 (3) | 23.3 (7) | 23.3 (88) | 0.4 | NS | NS | NS |
A9 | 36.0 (9) | 30.0 (9) | 28.6 (108) | 1.4 | NS | NS | NS |
A10 | 12.0 (3) | 3.3 (1) | 10.6 (40) | 1.1 | NS | NS | NS |
A11 | 0.0 (0) | 16.7 (5) | 9.3 (35) | 0.2 | NS | NS | NS |
A19 | 36.0 (9) | 23.3 (7) | 33.4 (126) | 1.1 | NS | NS | NS |
A28 | 4.0 (1) | 0.0 (0) | 5.3 (20) | 0.7 | NS | NS | NS |
B5 | 24.0 (6) | 33.3 (10) | 27.3 (103) | 0.8 | NS | NS | NS |
B7 | 8.0 (2) | 16.7 (5) | 12.2 (46) | 0.6 | NS | NS | NS |
B8 | 40.0 (10) | 6.7 (2) | 10.1 (38) | 5.9 | 0.0005 | NS | NS* |
B12 | 16.0 (4) | 13.3 (4) | 15.4 (58) | 1.0 | NS | NS | NS |
B13 | 4.0 (1) | 3.3 (1) | 6.1 (23) | 0.6 | NS | NS | NS |
B14 | 16.0 (4) | 3.3 (1) | 6.9 (26) | 2.6 | NS | NS | NS |
B15 | 20.0 (5) | 13.3 (4) | 8.5 (32) | 2.7 | NS | NS | NS |
B16 | 8.0 (2) | 13.3 (4) | 9.0 (34) | 0.9 | NS | NS | NS |
B17 | 0.0 (0) | 10.0 (3) | 8.5 (32) | 0.2 | NS | NS | NS |
B18 | 32.0 (8) | 13.3 (4) | 13.3 (50) | 3.1 | NS† | NS | NS |
B21 | 0.0 (0) | 6.7 (2) | 8.5 (32) | 0.2 | NS | NS | NS |
B22 | 4.0 (1) | 0.0 (0) | 4.8 (18) | 0.8 | NS | NS | NS |
B27 | 0.0 (0) | 0.0 (0) | 2.4 (9) | 0.8 | NS | NS | NS |
B35 | 12.0 (3) | 36.7 (11) | 30.2 (114) | 0.3 | NS | NS | NS |
B37 | 0.0 (0) | 3.3 (1) | 1.6 (6) | 1.1 | NS | NS | NS |
B41 | 0.0 (0) | 0.0 (0) | 1.3 (5) | 1.3 | NS | NS | NS |
B42 | 0.0 (0) | 0.0 (0) | 0.5 (2) | 2.9 | NS | NS | NS |
B47 | 0.0 (0) | 0.0 (0) | 0.5 (2) | 2.9 | NS | NS | NS |
B53 | 0.0 (0) | 0.0 (0) | 0.5 (2) | 2.9 | NS | NS | NS |
Alleles . | Patients (%) n = 25 . | Pathological Controls (%) n = 30 . | Normal Controls (%) n = 377 . | RR . | pcI . | pcII . | pcIII . |
---|---|---|---|---|---|---|---|
A1 | 24.0 (6) | 16.7 (5) | 22.5 (85) | 1.1 | NS | NS | NS |
A2 | 60.0 (15) | 56.7 (17) | 46.1 (174) | 1.7 | NS | NS | NS |
A3 | 12.0 (3) | 23.3 (7) | 23.3 (88) | 0.4 | NS | NS | NS |
A9 | 36.0 (9) | 30.0 (9) | 28.6 (108) | 1.4 | NS | NS | NS |
A10 | 12.0 (3) | 3.3 (1) | 10.6 (40) | 1.1 | NS | NS | NS |
A11 | 0.0 (0) | 16.7 (5) | 9.3 (35) | 0.2 | NS | NS | NS |
A19 | 36.0 (9) | 23.3 (7) | 33.4 (126) | 1.1 | NS | NS | NS |
A28 | 4.0 (1) | 0.0 (0) | 5.3 (20) | 0.7 | NS | NS | NS |
B5 | 24.0 (6) | 33.3 (10) | 27.3 (103) | 0.8 | NS | NS | NS |
B7 | 8.0 (2) | 16.7 (5) | 12.2 (46) | 0.6 | NS | NS | NS |
B8 | 40.0 (10) | 6.7 (2) | 10.1 (38) | 5.9 | 0.0005 | NS | NS* |
B12 | 16.0 (4) | 13.3 (4) | 15.4 (58) | 1.0 | NS | NS | NS |
B13 | 4.0 (1) | 3.3 (1) | 6.1 (23) | 0.6 | NS | NS | NS |
B14 | 16.0 (4) | 3.3 (1) | 6.9 (26) | 2.6 | NS | NS | NS |
B15 | 20.0 (5) | 13.3 (4) | 8.5 (32) | 2.7 | NS | NS | NS |
B16 | 8.0 (2) | 13.3 (4) | 9.0 (34) | 0.9 | NS | NS | NS |
B17 | 0.0 (0) | 10.0 (3) | 8.5 (32) | 0.2 | NS | NS | NS |
B18 | 32.0 (8) | 13.3 (4) | 13.3 (50) | 3.1 | NS† | NS | NS |
B21 | 0.0 (0) | 6.7 (2) | 8.5 (32) | 0.2 | NS | NS | NS |
B22 | 4.0 (1) | 0.0 (0) | 4.8 (18) | 0.8 | NS | NS | NS |
B27 | 0.0 (0) | 0.0 (0) | 2.4 (9) | 0.8 | NS | NS | NS |
B35 | 12.0 (3) | 36.7 (11) | 30.2 (114) | 0.3 | NS | NS | NS |
B37 | 0.0 (0) | 3.3 (1) | 1.6 (6) | 1.1 | NS | NS | NS |
B41 | 0.0 (0) | 0.0 (0) | 1.3 (5) | 1.3 | NS | NS | NS |
B42 | 0.0 (0) | 0.0 (0) | 0.5 (2) | 2.9 | NS | NS | NS |
B47 | 0.0 (0) | 0.0 (0) | 0.5 (2) | 2.9 | NS | NS | NS |
B53 | 0.0 (0) | 0.0 (0) | 0.5 (2) | 2.9 | NS | NS | NS |
pcI = pc patients versus normal controls; pcII = pc pathological controls versus normal controls; pcIII = pc patients versus pathological controls. RR was calculated comparing patients to normal controls. NS indicates Pc values less than 0.05. Symbols indicate all the differences that were significant before P values were corrected for the aggregate HLA antigens tested (Pc).
P = .007.
P = .017.