Cytokine Binding Avidities and Capacities of Pharmaceutic IgG Preparations
| Cytokine . | Gammagard . | Sandoglobulin . | Nordimmun . | |||
|---|---|---|---|---|---|---|
| Kav (pmol/L) . | Bmax (μmol/mol) . | Kav (pmol/L) . | Bmax (μmol/mol) . | Kav (pmol/L) . | Bmax (μmol/mol) . | |
| GM-CSF | 6 | 5 | 8 | 1.3 | 8 | 1.3 |
| 11 | 2.8 | 6 | 1.4 | 7 | 1 | |
| 4 | 4.2 | 6 | 1.1 | 9 | 1.3 | |
| 7 | 2.9 | 9 | 0.24 | |||
| IL-5 | 15 | 1.3 | ||||
| IL-10 | 108 | 0.12 | 80 | 0.1 | 380 | 0.3 |
| 351 | 0.4 | |||||
| Cytokine . | Gammagard . | Sandoglobulin . | Nordimmun . | |||
|---|---|---|---|---|---|---|
| Kav (pmol/L) . | Bmax (μmol/mol) . | Kav (pmol/L) . | Bmax (μmol/mol) . | Kav (pmol/L) . | Bmax (μmol/mol) . | |
| GM-CSF | 6 | 5 | 8 | 1.3 | 8 | 1.3 |
| 11 | 2.8 | 6 | 1.4 | 7 | 1 | |
| 4 | 4.2 | 6 | 1.1 | 9 | 1.3 | |
| 7 | 2.9 | 9 | 0.24 | |||
| IL-5 | 15 | 1.3 | ||||
| IL-10 | 108 | 0.12 | 80 | 0.1 | 380 | 0.3 |
| 351 | 0.4 | |||||
GM-CSF binding was tested with individual batches of 0.2 to 10 mg IgG/mL (giving similar binding activity). For IL-5 and IL-10, the assays were performed with 2 and 15 to 20 mg IgG/mL, respectively.