Comparative Effect of 12 Polar Head Analogs on P falciparum Growth (IC50) and Lymphoblastoid Cell Viability (LV50)
| Compounds . | IC50 (μmol/L) . | LV50(μmol/L) . |
|---|---|---|
| E3 | 1.6 | 6.6 |
| E8 | 0.8 | 14 |
| F2 | 81.3 | 18,000 |
| F3 | 0.97 | 85 |
| F4 | 0.48 | 3.7 |
| F8 | 0.34 | 0.85 |
| F13 | 110 | 4,700 |
| G3 | 1.7 | 9,500 |
| G4 | 0.09 | 95 |
| G23 | 0.15 | 2,500 |
| H3 | 2 | 9,500 |
| HC3 | 4 | 7,000 |
| Compounds . | IC50 (μmol/L) . | LV50(μmol/L) . |
|---|---|---|
| E3 | 1.6 | 6.6 |
| E8 | 0.8 | 14 |
| F2 | 81.3 | 18,000 |
| F3 | 0.97 | 85 |
| F4 | 0.48 | 3.7 |
| F8 | 0.34 | 0.85 |
| F13 | 110 | 4,700 |
| G3 | 1.7 | 9,500 |
| G4 | 0.09 | 95 |
| G23 | 0.15 | 2,500 |
| H3 | 2 | 9,500 |
| HC3 | 4 | 7,000 |
LV50 were measured after 24 hours of drug contact with cells as described in the Materials and Methods. IC50against P falciparum are from Table 1.