Assessment of Bleeding
| Dog No. . | Treatment . | Bleeding Time (min) . | Rate of Blood Flow (mL/min) . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| . | . | 0 h . | 0.5 h . | 3 h . | 24 h . | 0 h . | 0.5 h . | 3 h . | 24 h . |
| vWF-deficient | |||||||||
| 750 | rvWF | >15 | >15 | >15 | >15 | 3.28 | 0.40 | 0.15 | 2.15 |
| 751 | rvWF | >15 | >15 | >15 | >15 | 2.53 | 0.34 | 1.54 | 0.67 |
| pdvWF | >15 | >15 | >15 | >15 | 0.26 | 0.32 | 0.08 | 0.15 | |
| 1140 | LMW-rvWF | >15 | >15 | >15 | >15 | 0.18 | 0.06 | 0.19 | 1.08 |
| Normal | |||||||||
| H9510176 | rvWF | 6 | 4 | 5 | 6 | 0.00 | 0.00 | 0.00 | 0.00 |
| pdvWF | 9 | 6 | 2 | 6 | 0.00 | 0.00 | 0.00 | 0.00 | |
| Dog No. . | Treatment . | Bleeding Time (min) . | Rate of Blood Flow (mL/min) . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| . | . | 0 h . | 0.5 h . | 3 h . | 24 h . | 0 h . | 0.5 h . | 3 h . | 24 h . |
| vWF-deficient | |||||||||
| 750 | rvWF | >15 | >15 | >15 | >15 | 3.28 | 0.40 | 0.15 | 2.15 |
| 751 | rvWF | >15 | >15 | >15 | >15 | 2.53 | 0.34 | 1.54 | 0.67 |
| pdvWF | >15 | >15 | >15 | >15 | 0.26 | 0.32 | 0.08 | 0.15 | |
| 1140 | LMW-rvWF | >15 | >15 | >15 | >15 | 0.18 | 0.06 | 0.19 | 1.08 |
| Normal | |||||||||
| H9510176 | rvWF | 6 | 4 | 5 | 6 | 0.00 | 0.00 | 0.00 | 0.00 |
| pdvWF | 9 | 6 | 2 | 6 | 0.00 | 0.00 | 0.00 | 0.00 | |
An incision was made in a nail cuticle at baseline (0 hour) and 0.5, 3, and 24 hours after administration of a single bolus injection of rvWF, LMW-rvWF, or pdvWF. Bleeding time was measured and the rate of blood flow was assessed during an observation interval from 8 to 15 minutes after each incision.