Biological Activity of Human RvWF, LMW-rvWF, and PdvWF in vWF-deficient and Normal Dogs
Dog No. . | Treatment . | Dose . | Half-Life . | In Vivo Recovery . | Maximum Increase in FVIII Activity . | Time to Reach Max. FVIII Activity . | |||
---|---|---|---|---|---|---|---|---|---|
. | . | vWF:Ag (mg/kg) . | RCoF (U/kg) . | vWF:Ag (h) . | RCoF (h) . | vWF:Ag (%) . | RCoF (%) . | FVIII 2-Stage (%) . | FVIII 2-Stage (h) . |
vWF-deficient | |||||||||
750 | rvWF | 46 | 35 | 22.1 | 4.7 | 64 | 78 | 173 | 24 |
751 | rvWF | 92 | 70 | 21.6 | 9.8 | 70 | 120 | 244 | 48 |
pdvWF | 10 | 63 | 7.7 | NE3-150 | 33 | 25 | 140 | 48 | |
754 | rvWF | 97 | 75 | NE3-151 | NE3-151 | 59 | 110 | 226 | 48 |
1140 | LMW-rvWF | 45 | 6 | 9.0 | NE3-150 | 92 | NE3-150 | 195 | 48 |
Normal | |||||||||
H9510176 | rvWF | 45 | 35 | 14.5 | 6.5 | 33 | 96 | NE | NE |
pdvWF | 7.2 | 32 | 9.0 | 3.2 | 37 | 59 | NE | NE |
Dog No. . | Treatment . | Dose . | Half-Life . | In Vivo Recovery . | Maximum Increase in FVIII Activity . | Time to Reach Max. FVIII Activity . | |||
---|---|---|---|---|---|---|---|---|---|
. | . | vWF:Ag (mg/kg) . | RCoF (U/kg) . | vWF:Ag (h) . | RCoF (h) . | vWF:Ag (%) . | RCoF (%) . | FVIII 2-Stage (%) . | FVIII 2-Stage (h) . |
vWF-deficient | |||||||||
750 | rvWF | 46 | 35 | 22.1 | 4.7 | 64 | 78 | 173 | 24 |
751 | rvWF | 92 | 70 | 21.6 | 9.8 | 70 | 120 | 244 | 48 |
pdvWF | 10 | 63 | 7.7 | NE3-150 | 33 | 25 | 140 | 48 | |
754 | rvWF | 97 | 75 | NE3-151 | NE3-151 | 59 | 110 | 226 | 48 |
1140 | LMW-rvWF | 45 | 6 | 9.0 | NE3-150 | 92 | NE3-150 | 195 | 48 |
Normal | |||||||||
H9510176 | rvWF | 45 | 35 | 14.5 | 6.5 | 33 | 96 | NE | NE |
pdvWF | 7.2 | 32 | 9.0 | 3.2 | 37 | 59 | NE | NE |