Summary of the Six Surviving Children Born With Homozygous α-Thalassemia
Previous Birth of Hydropic Infant . | Birth . | Transfusion Treatment . | Duration in Hospital After Birth . | Follow-Up . | References . |
---|---|---|---|---|---|
No | Caesarean section at 32 wk | Postdelivery transfusion | 48 d | At 6 yr, delay in speech and hearing | 62, 64 |
Yes | Caesarean section at 28 wk | Postdelivery transfusion | 73 d | At 5 yr, normal development | 63, 64 |
Not recorded | Vaginal delivery with breech presentation at 28 wk | Postdelivery transfusion | 64 d | At 10 mo, mild gross motor delay | 64 |
No | Caesarean section at 31 wk, as part of triplet delivery | Postdelivery transfusion | 2½ mo | At 2 yr, spastic quadriplegia and profound developmental delay | 65 |
Yes | Caesarean section at 34 wk | Intrauterine transfusion beginning at 25 wk | 11 d | Several congenital anomalies. At 2 yr, developmental delay in cognitive and motor functions | 55, 66 |
No | Caesarean section at 37 wk | Intrauterine transfusion beginning at 32 wk | 30 d | At 3 yr, normal neurological assessment | 67 |
Previous Birth of Hydropic Infant . | Birth . | Transfusion Treatment . | Duration in Hospital After Birth . | Follow-Up . | References . |
---|---|---|---|---|---|
No | Caesarean section at 32 wk | Postdelivery transfusion | 48 d | At 6 yr, delay in speech and hearing | 62, 64 |
Yes | Caesarean section at 28 wk | Postdelivery transfusion | 73 d | At 5 yr, normal development | 63, 64 |
Not recorded | Vaginal delivery with breech presentation at 28 wk | Postdelivery transfusion | 64 d | At 10 mo, mild gross motor delay | 64 |
No | Caesarean section at 31 wk, as part of triplet delivery | Postdelivery transfusion | 2½ mo | At 2 yr, spastic quadriplegia and profound developmental delay | 65 |
Yes | Caesarean section at 34 wk | Intrauterine transfusion beginning at 25 wk | 11 d | Several congenital anomalies. At 2 yr, developmental delay in cognitive and motor functions | 55, 66 |
No | Caesarean section at 37 wk | Intrauterine transfusion beginning at 32 wk | 30 d | At 3 yr, normal neurological assessment | 67 |